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Literature summary for 2.7.4.3 extracted from

  • Amiri, M.; Conserva, F.; Panayiotou, C.; Karlsson, A.; Solaroli, N.
    The human adenylate kinase 9 is a nucleoside mono- and diphosphate kinase (2013), Int. J. Biochem. Cell Biol., 45, 925-931.
    View publication on PubMed
Search for more literature for 2.7.4.3

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) cells Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.048
-
 AMP in 50 mM Tris-HCl pH 7.6, 5 mM MgCl2, at 37°C Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48500
-
 x * 48500, calculated from amino acid sequence Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain moderate expression Homo sapiens
-
lymph node moderate expression Homo sapiens
-
mammary gland high expression level Homo sapiens
-
pharynx moderate expression Homo sapiens
-
pituitary gland high expression level Homo sapiens
-
spleen moderate expression Homo sapiens
-
testis high expression level Homo sapiens
-
thymus high expression level Homo sapiens
-
trachea high expression level Homo sapiens
-
uterus moderate expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + AMP
-
 Homo sapiens ADP + ADP
-
 ?
additional information the enzyme catalyzes the phosphorylation of AMP (highest affinity), dAMP, CMP and dCMP with ATP as phosphate donor, while only AMP and CMP are phosphorylated when GTP is the phosphate donor. With ATP or GTP as phosphate donor it was possible to detect the production of ATP, CTP, GTP, UTP, dATP, dCTP, dGTP and TTP as enzymatic products from the corresponding diphosphate substrates Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
? x * 48500, calculated from amino acid sequence Homo sapiens

Synonyms

Synonyms Comment Organism
adenylate kinase 9
-
 Homo sapiens
AK9
-
 Homo sapiens

pI Value

Organism Comment pI Value Maximum pI Value
Homo sapiens calculated from amino acid sequence
-
 4.9