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Literature summary for 2.7.4.3 extracted from

  • Burkart, A.; Shi, X.; Chouinard, M.; Corvera, S.
    Adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response (2011), J. Biol. Chem., 286, 4081-4089.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.4.3

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
3T3-L1 cell
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + AMP
-
 Mus musculus 2 ADP
-
 ?

Synonyms

Synonyms Comment Organism
adenylate kinase 2
-
 Mus musculus
AK2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus adenylate kinase 2 is markedly induced during adipocyte and B cell differentiation up

General Information

General Information Comment Organism
malfunction depletion of adenylate kinase 2 (AK2) by RNAi impairs adiponectin secretion in 3T3-L1 adipocytes, immunoglobulin M secretion in BCL1 cells, and the induction of the unfolded protein response during differentiation of both cell types. Depletion of AK2 results in changes in adipocyte energy homeostasis, but these effects do not detectably impair key adipocyte properties such as mitochondrial biogenesis and triglyceride storage Mus musculus
metabolism adenylate kinase 2 links mitochondrial energy metabolism to the induction of the unfolded protein response Mus musculus