Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | dependent on Mg2+ | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AMP | Escherichia coli | - |
2 ADP | - |
? | |
ATP + AMP | Escherichia coli K12 | - |
2 ADP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | P69441 | - |
- |
Escherichia coli K12 | P69441 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + AMP | - |
Escherichia coli | 2 ADP | - |
? | |
ATP + AMP | the enzyme has 3 domains, the LID, NMP, and CORE domains, that undergo large conformational rearrangements during catalytic cycle of adenylate kinase. The pathway from open to closed forms is explored using coarse-grained molecular dynamics trajectories of adenosine kinase calculated by GROMACS using a SMOG model and classify the conformations within the resultant trajectories by K-means clustering | Escherichia coli | 2 ADP | - |
? | |
ATP + AMP | - |
Escherichia coli K12 | 2 ADP | - |
? | |
ATP + AMP | the enzyme has 3 domains, the LID, NMP, and CORE domains, that undergo large conformational rearrangements during catalytic cycle of adenylate kinase. The pathway from open to closed forms is explored using coarse-grained molecular dynamics trajectories of adenosine kinase calculated by GROMACS using a SMOG model and classify the conformations within the resultant trajectories by K-means clustering | Escherichia coli K12 | 2 ADP | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | the reaction is a major player in cellular energy homeostasis and the isoform network of adenylate kinase plays an important role in AMP metabolic signaling circuits | Escherichia coli |