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Literature summary for 2.7.4.9 extracted from

  • Bone, R.; Cheng, Y.C.; Wolfenden, R.
    Inhibition of adenosine and thymidylate kinases by bisubstrate analogs (1986), J. Biol. Chem., 261, 16410-16413.
    View publication on PubMed
Search for more literature for 2.7.4.9

Inhibitors

Inhibitors Comment Organism Structure
P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate
-
 Homo sapiens
P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate
-
 Homo sapiens
P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blast cell peripheral blast cell obtained from acute myelocytic leukemia patients Homo sapiens
-

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00018
-
 P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate pH 7.5, 37°C, with dTMP as variable substrate and ATP as cosubstrate Homo sapiens
0.0002
-
 P1-(Adenosine 5')-P6-(thymidine 5')-hexaphosphate pH 7.5, 37°C, with ATP as variable substrate and dTMP as cosubstrate Homo sapiens
0.00047
-
 P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate pH 7.5, 37°C, with dTMP as variable substrate and ATP as cosubstrate Homo sapiens
0.0006
-
 P1-(adenosine 5')-P5-(thymidine 5')-pentaphosphate pH 7.5, 37°C, with ATP as variable substrate and dTMP as cosubstrate Homo sapiens
0.0175
-
 P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate pH 7.5, 37°C, with dTMP as variable substrate and ATP as cosubstrate Homo sapiens
0.0209
-
 P1-(adenosine 5')-P4-(thymidine 5')-tetraphosphate pH 7.5, 37°C, with ATP as variable substrate and dTMP as cosubstrate Homo sapiens