Application | Comment | Organism |
---|---|---|
drug development | potential target for the development of antituberculosis drugs | Mycobacterium tuberculosis |
Crystallization (Comment) | Organism |
---|---|
cocrystals with 3-azido-3-deoxythymidine 5'-monophosphate and deoxythymidine | Mycobacterium tuberculosis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3'-azido-3'-deoxythymidine | - |
Mycobacterium tuberculosis | |
3'-azido-3'-deoxythymidine 5'-monophosphate | - |
Mycobacterium tuberculosis | |
deoxythymidine | - |
Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | bound to enzyme, displacement of Mg2+ is responsible for inhibitory effect of 3-azido-3-deoxythymidine 5'-monophosphate | Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dTMP | Mycobacterium tuberculosis | involved in dTTP metabolism, essential for cell proliferation | ADP + dTDP | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WKE1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dTMP | - |
Mycobacterium tuberculosis | ADP + dTDP | - |
r | |
ATP + dTMP | involved in dTTP metabolism, essential for cell proliferation | Mycobacterium tuberculosis | ADP + dTDP | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | crystal structure analysis | Mycobacterium tuberculosis |