Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Plasmodium falciparum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
dAMP | 5 mM, about 15% inhibition | Plasmodium falciparum | |
dUMP | 5 mM, about 15% inhibition | Plasmodium falciparum | |
EDTA | 4 mM, 80% loss of activity | Plasmodium falciparum | |
additional information | not inhibitory: 2-mercaptoethanol up to 5 mM, AMP, CMP, dCMP, GMP and dGMP and | Plasmodium falciparum | |
UMP | 5 mM, about 15% inhibition | Plasmodium falciparum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.022 | - |
dTMP | pH 7.2, 30°C | Plasmodium falciparum | |
0.03 | - |
dGMP | pH 7.2, 30°C | Plasmodium falciparum | |
0.577 | - |
dIMP | pH 7.2, 30°C | Plasmodium falciparum | |
0.78 | - |
dUMP | pH 7.2, 30°C | Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
2.2 | - |
substrate dIMP, pH 7.2, 30°C | Plasmodium falciparum |
6.5 | - |
substrate dUMP, pH 7.2, 30°C | Plasmodium falciparum |
13 | - |
substrate dGMP, pH 7.2, 30°C | Plasmodium falciparum |
15 | - |
substrate dTMP, pH 7.2, 30°C | Plasmodium falciparum |
Storage Stability | Organism |
---|---|
-20°C, 2 months, no loss of activity | Plasmodium falciparum |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dGMP | 86% of the activity with dTMP | Plasmodium falciparum | ADP + dGDP | - |
? | |
ATP + dIMP | 15% of the activity with dTMP | Plasmodium falciparum | ADP + dIDP | - |
? | |
ATP + dTMP | - |
Plasmodium falciparum | ADP + dTDP | - |
? | |
ATP + dUMP | 43% of the activity with dTMP | Plasmodium falciparum | ADP + dUDP | - |
? | |
ATP + GMP | 1.5% of the activity with dTMP | Plasmodium falciparum | ADP + GDP | - |
? | |
dATP + dTMP | dATP, 64% of the activity with ATP | Plasmodium falciparum | dADP + dTDP | - |
? |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
10 min, 30% residual activity | Plasmodium falciparum |
65 | - |
10 min, complete loss of activity | Plasmodium falciparum |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.44 | - |
dIMP | pH 7.2, 30°C | Plasmodium falciparum | |
2.9 | - |
dGMP | pH 7.2, 30°C | Plasmodium falciparum | |
3.4 | - |
dTMP | pH 7.2, 30°C | Plasmodium falciparum | |
4.1 | - |
dUMP | pH 7.2, 30°C | Plasmodium falciparum |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | - |
marked drop in activity below | Plasmodium falciparum |
7 | 9 | - |
Plasmodium falciparum |