Crystallization (Comment) | Organism |
---|---|
molecular docking studies using inhibitors (4E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one, 1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-5-methylpyrimidine-2,4-(1H,3H)-dione, 5-bromo-1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-pyrimidine-2,4-(1H,3H)-dione | Wolbachia endosymbiont of Brugia malayi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(4E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one | i.e. [6]-shogaol, isolated from Zingiber officinale | Wolbachia endosymbiont of Brugia malayi | |
1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-5-methylpyrimidine-2,4-(1H,3H)-dione | i.e. shogaol with thymine head group | Wolbachia endosymbiont of Brugia malayi | |
5-bromo-1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-pyrimidine-2,4-(1H,3H)-dione | i.e. shogaol with bromouracil head group | Wolbachia endosymbiont of Brugia malayi |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.017 | - |
dTMP | pH 7.4, temperature not specified in the publication | Wolbachia endosymbiont of Brugia malayi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | Q5GTD5 | - |
- |
Wolbachia endosymbiont of Brugia malayi TRS | Q5GTD5 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + dTMP | - |
Wolbachia endosymbiont of Brugia malayi | ADP + dTDP | - |
? | |
ATP + dTMP | - |
Wolbachia endosymbiont of Brugia malayi TRS | ADP + dTDP | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0066 | - |
1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-5-methylpyrimidine-2,4-(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Wolbachia endosymbiont of Brugia malayi | |
0.0083 | - |
5-bromo-1-(1-(4-hydroxy-3-methoxyphenyl)-3-oxodecan-5-yl)-pyrimidine-2,4-(1H,3H)-dione | pH 7.4, temperature not specified in the publication | Wolbachia endosymbiont of Brugia malayi | |
0.0108 | - |
(4E)-1-(4-hydroxy-3-methoxyphenyl)dec-4-en-3-one | pH 7.4, temperature not specified in the publication | Wolbachia endosymbiont of Brugia malayi |