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Literature summary for 2.7.6.1 extracted from

  • Switzer, R.L.; Sogin, D.C.
    Regulation and mechanism of phosphoribosylpyrophosphate synthetase. V. Inhibition by end products and regulation by adenosine diphosphate (1973), J. Biol. Chem., 248, 1063-1073.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
ADP non competitive with respect to ATP at 0.2 mM D-ribose-5-phosphate; the most effective Salmonella enterica subsp. enterica serovar Typhimurium
Ca2+ low concentrations of CaCl2 in the presence of an excess of MgCl2 result in a reduction in catalytic activity. At CaCl2 1 mM, the enzyme is less sensitive to ADP inhibition Salmonella enterica subsp. enterica serovar Typhimurium
CTP the most effective pyrimidine nucleotide inhibitor Salmonella enterica subsp. enterica serovar Typhimurium
D-fructose 1,6-diphosphate no inhibition Salmonella enterica subsp. enterica serovar Typhimurium
D-Fructose 1-phosphate no inhibition Salmonella enterica subsp. enterica serovar Typhimurium
D-ribose 5-phosphate inhibition in presence of Ca2+, without ADP; substrate inhibition in presence of ADP, not in its absence Salmonella enterica subsp. enterica serovar Typhimurium
dADP induces substrate inhibition by D-ribose-5-phosphate Salmonella enterica subsp. enterica serovar Typhimurium
GDP below 3-4 mM, linear competitive inhibition with respect to ATP Salmonella enterica subsp. enterica serovar Typhimurium
GTP below 3-4 mM, linear competitive inhibition with respect to ATP Salmonella enterica subsp. enterica serovar Typhimurium
IDP below 3-4 mM, linear competitive inhibition with respect to ATP Salmonella enterica subsp. enterica serovar Typhimurium
ITP below 3-4 mM, linear competitive inhibition with respect to ATP Salmonella enterica subsp. enterica serovar Typhimurium
L-histidine no inhibition Salmonella enterica subsp. enterica serovar Typhimurium
L-tryptophan no inhibition Salmonella enterica subsp. enterica serovar Typhimurium
additional information 6-phosphogluconate, 3-phosphoglycerate, phosphoenolpyruvate and ribulose-5-phosphate have no effect on the activity; D-glucose-6-phosphate have no effects on the enzyme activity; purines are more effective than pyrimidines, nucleoside tri and diphosphates are more effective than monophosphates, ribonucleotides are more effective than deoxynucleotides Salmonella enterica subsp. enterica serovar Typhimurium
nucleotides purines more effective than pyrimidines Salmonella enterica subsp. enterica serovar Typhimurium
UDP
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Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + D-ribose 5-phosphate Salmonella enterica subsp. enterica serovar Typhimurium the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan AMP + 5-phospho-alpha-D-ribose 1-diphosphate
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r

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + D-ribose 5-phosphate
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Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
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r
ATP + D-ribose 5-phosphate the product phosphoribosyldiphosphate is required for the biosynthesis of purine, pyrimidine and pyridine nucleotides, L-histidine and L-tryptophan Salmonella enterica subsp. enterica serovar Typhimurium AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
r