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Literature summary for 2.7.7.41 extracted from

  • Martin, D.; Gannoun-Zaki, L.; Bonnefoy, S.; Eldin, P.; Wengelnik, K.; Vial, H.
    Characterization of Plasmodium falciparum CDP-diacylglycerol synthase, a proteolytically cleaved enzyme (2000), Mol. Biochem. Parasitol., 110, 93-105.
    View publication on PubMed
Search for more literature for 2.7.7.41

Cloned(Commentary)

Cloned (Comment) Organism
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
CTP + phosphatidate Plasmodium falciparum the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids diphosphate + CDPdiacylglycerol
-
 ?

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum Q9NIH5
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification N-terminal proteolytical processing form a protein of 51000 Da and a protein of 28000 Da from the 78000 Da protein Plasmodium falciparum

Source Tissue

Source Tissue Comment Organism Textmining
ring stage the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages Plasmodium falciparum
-
schizont the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages Plasmodium falciparum
-
trophozoite the enzyme is only weakly transcribed in ring stages, while major transcription occurs in the trophozoite and schizont stages Plasmodium falciparum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
CTP + phosphatidate
-
 Plasmodium falciparum diphosphate + CDPdiacylglycerol
-
 ?
CTP + phosphatidate the enzyme catalyzes the synthesis of CDPdiacylglycerol, an obligatory intermediate compound in the biosynthesis of the major anionic and zwitterionic phospholipids Plasmodium falciparum diphosphate + CDPdiacylglycerol
-
 ?

Subunits

Subunits Comment Organism
?
-
 Plasmodium falciparum

pI Value

Organism Comment pI Value Maximum pI Value
Plasmodium falciparum calculated from nucleotide sequence for full-length enzyme
-
 9.62