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Literature summary for 2.7.7.41 extracted from

  • Serricchio, M.; Buetikofer, P.
    Phosphatidylglycerophosphate synthase associates with a mitochondrial inner membrane complex and is essential for growth of Trypanosoma brucei (2013), Mol. Microbiol., 87, 569-579.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei brucei Q57U32
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Trypanosoma brucei brucei 927 / 4 GUTat10.1 / TREU927 Q57U32
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Synonyms

Synonyms Comment Organism
Tb927.7.220
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Trypanosoma brucei brucei

General Information

General Information Comment Organism
physiological function CDS gene expression is essential in the bloodstream form of the parasite. A CDS conditional knockout shows morphological changes including a cell-cycle arrest due in part to kinetoplast segregation defects. The conditional knockout shows drastically altered lipid metabolism where reducing levels of phosphatidylinositol detrimentally impact on glycoylphosphatidylinositol biosynthesis. Expression of Trypanosoma brucei CDS gene complements a non-viable yeast CDS null strain Trypanosoma brucei brucei