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Literature summary for 2.7.7.43 extracted from
- Partial purification and characterization of cytidine-5-monophosphosialate synthase from rainbow trout liver (1993), Biol. Chem. Hoppe-Seyler, 374, 337-342.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2'-deoxy-CTP | 0.3 mM; 44% inhibition | Oncorhynchus mykiss |  |
| CDP | 0.3 mM, 45% inhibition | Oncorhynchus mykiss | |
| CMP | 0.3 mM, 57% inhibition | Oncorhynchus mykiss | |
| Cu2+ | 1 mM, 21% inhibition | Oncorhynchus mykiss | |
| Hg2+ | 1 mM, 33% inhibition | Oncorhynchus mykiss | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 1.7 | - |
CTP | pH 9.3, 30°C | Oncorhynchus mykiss | |
| 2.1 | - |
N-acetylneuraminate | pH 9.3, 30°C | Oncorhynchus mykiss | |
| 2.9 | - |
N-glycolylneuraminate | pH 9.3, 30°C | Oncorhynchus mykiss | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 160000 | - |
gel filtration | Oncorhynchus mykiss |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oncorhynchus mykiss | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Oncorhynchus mykiss |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Oncorhynchus mykiss |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| CTP + N-acylneuraminate | - |
Oncorhynchus mykiss | diphosphate + CMP-N-acylneuraminate | - |
? | |
| CTP + N-glycolylneuraminate | - |
Oncorhynchus mykiss | diphosphate + CMP-N-glycolylneuraminate | - |
? | |
| additional information | no activity with N-acetyl-9-O-acetylneuraminate | Oncorhynchus mykiss | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 28 | - |
- |
Oncorhynchus mykiss |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9.3 | - |
- |
Oncorhynchus mykiss |
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Release 2023.1 (January 2023)
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