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Literature summary for 2.7.7.47 extracted from

  • Harwood, J.H.; Smith, D.H.
    Resistance factor-mediated streptomycin resistance (1969), J. Bacteriol., 97, 1262-1271.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.47

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol enhances the degree of streptomycin inactivation Escherichia coli
Tris-HCl
-
 Escherichia coli

Localization

Localization Comment Organism GeneOntology No. Textmining
extrachromosomal DNA resistance factor RE130, extrachromosomal genetic element Escherichia coli 46821
-
periplasm periplasmic space Escherichia coli
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required for activity in vitro Escherichia coli
additional information Ni2+, Co2+, Ca2+, Zn2+ and Mn2+ cannot replace Mg2+ Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + streptomycin Escherichia coli enzyme leads to resistance, destroys the inhibitory activity of streptomycin diphosphate + 3''-adenylylstreptomycin
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
 strain W, AB1932
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + bluensomycin
-
 Escherichia coli diphosphate + 3''-adenylylbluensomycin
-
 ?
ATP + spectinomycin
-
 Escherichia coli diphosphate + 9-adenylylspectinomycin
-
 ?
ATP + streptobiosamine degradation product streptomycin Escherichia coli diphosphate + 3''-adenylylstreptobiosamine
-
 ?
ATP + streptomycin
-
 Escherichia coli diphosphate + 3''-adenylylstreptomycin
-
 ?
ATP + streptomycin enzyme leads to resistance, destroys the inhibitory activity of streptomycin Escherichia coli diphosphate + 3''-adenylylstreptomycin
-
 ?
additional information ADP, AMP, UTP, GTP, CTP, TTP, dAMP, adenine, adenosine, S-adenosyl methionine, dADP and ADPglucose are ineffective, streptidine cannot be adenylated by the enzyme, kanamycin and neomycin are not adenylated Escherichia coli ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.3
-
-
 Escherichia coli

Cofactor

Cofactor Comment Organism Structure
ATP
-
 Escherichia coli
dATP
-
 Escherichia coli
additional information ADP, AMP, adenosine, adenine other nucleoside triphosphates or other deoxyadenine-containing compounds cannot replace ATP Escherichia coli