Literature summary for 2.7.7.48 extracted from

Rohayem, J.; Jaeger, K.; Robel, I.; Scheffler, U.; Temme, A.; Rudolph, W.
Characterization of norovirus 3Dpol RNA-dependent RNA polymerase activity and initiation of RNA synthesis (2006), J. Gen. Virol., 87, 2621-2630.

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Cloned(Commentary)

Cloned (Comment)	Organism
recombinant NV 3Dpol, as well as a 3Dpol active-site mutant are expressed in Escherichia coli	Norovirus Hu/NLV/Dresden174/pUS-NorII/1997/GE

Organism

Organism	UniProt	Comment	Textmining
Norovirus Hu/NLV/Dresden174/pUS-NorII/1997/GE	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Norovirus Hu/NLV/Dresden174/pUS-NorII/1997/GE

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	NV 3Dpol yields two different products when incubated with synthetic RNA in vitro: (1) a double-stranded RNA consisting of two single strands of opposite polarity or (2) the single-stranded RNA template labelled at its 39 terminus by terminal transferase activity. Initiation of RNA synthesis by NV 3Dpol on heteromeric RNA template occurs de novo	Norovirus Hu/NLV/Dresden174/pUS-NorII/1997/GE	diphosphate + RNAn+1	-	?

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Release 2023.1 (January 2023)