Literature summary for 2.7.7.48 extracted from

Arias, A.; Arnold, J.J.; Sierra, M.; Smidansky, E.; Domingo, E.; Cameron, C.E.
Determinants of RNA-dependent RNA polymerase (in)fidelity revealed by kinetic analysis of the polymerase encoded by a foot-and-mouth disease virus mutant with reduced sensitivity to ribavirin (2008), J. Virol., 82, 12346-12355.

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Protein Variants

Protein Variants	Comment	Organism
M296I	the mutant exhibits reduced sensitivity to ribavirin	Foot-and-mouth disease virus

Inhibitors

Inhibitors	Comment	Organism	Structure
ribavirin	-	Foot-and-mouth disease virus

Organism

Organism	UniProt	Comment	Textmining
Foot-and-mouth disease virus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
nucleoside triphosphate + RNAn	-	Foot-and-mouth disease virus	diphosphate + RNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
3Dpol	-	Foot-and-mouth disease virus
RNA-dependent RNA polymerase	-	Foot-and-mouth disease virus

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Release 2023.1 (January 2023)