Activating Compound | Comment | Organism | Structure |
---|---|---|---|
phosphoprotein P | P is essential for RNA-dependent RNA polymerase function as cofactor. The amino terminus of P is essential for its function in a minireplicon assay. It binds to STAT1 and inhibits interferon-induced Tyr phosphorylation of STAT1, which is not required for P polymerase cofactor function, since mutations in the STAT1 binding motif of P, e.g. G121E, do not affect RNA polymerase function, but abrogate STAT1 inhibition, overview. The gene for NiV P encodes functions that sequester inactive STAT1 in the nucleus, preventing its activation and suggest that the W protein is the dominant inhibitor of STAT1 in NiV-infected cells | Nipah henipavirus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Nipah henipavirus | - |
NiV | - |
Synonyms | Comment | Organism |
---|---|---|
RNA-dependent RNA polymerase | - |
Nipah henipavirus |