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Literature summary for 2.7.7.48 extracted from

  • Villordo, S.M.; Gamarnik, A.V.
    Genome cyclization as strategy for flavivirus RNA replication (2009), Virus Res., 139, 230-239.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.7.7.48

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Dengue virus NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis ?
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 ?
additional information Yellow fever virus NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis ?
-
 ?
additional information Japanese encephalitis virus NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis ?
-
 ?
additional information Saint Louis encephalitis virus NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis ?
-
 ?
additional information West Nile virus NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis ?
-
 ?
additional information Japanese encephalitis virus JEV NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis ?
-
 ?
additional information Saint Louis encephalitis virus SLEV NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis ?
-
 ?
additional information Dengue virus DENV NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis ?
-
 ?
additional information West Nile virus WNV NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Dengue virus
-
 DENV
-
Dengue virus DENV
-
 DENV
-
Japanese encephalitis virus
-
 JEV
-
Japanese encephalitis virus JEV
-
 JEV
-
Saint Louis encephalitis virus
-
 SLEV
-
Saint Louis encephalitis virus SLEV
-
 SLEV
-
West Nile virus P06935 WNV
-
West Nile virus WNV P06935 WNV
-
Yellow fever virus
-
 YFV
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information RdRp activity is associated with heavy cytoplasmic membrane fractions in the host cell Japanese encephalitis virus
-
additional information RdRp activity is associated with heavy cytoplasmic membrane fractions in the host cell Saint Louis encephalitis virus
-
additional information RdRp activity is associated with heavy cytoplasmic membrane fractions in the host cell West Nile virus
-
additional information RdRp activity is associated with heavy cytoplasmic membrane fractions in the host cell, a large fraction of the polymerase is also found in the nucleus of DENV-infected cells Dengue virus
-
additional information RdRp activity is associated with heavy cytoplasmic membrane fractions in the host cell, a large fraction of the polymerase is also found in the nucleus of YFV-infected cells Yellow fever virus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis Dengue virus ?
-
 ?
additional information NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis Yellow fever virus ?
-
 ?
additional information NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis Japanese encephalitis virus ?
-
 ?
additional information NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis Saint Louis encephalitis virus ?
-
 ?
additional information NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis West Nile virus ?
-
 ?
additional information formation of an RNA-RNA complex between the 5' and 3' terminal nucleotides of the viral genome is necessary for polymerase activity, template specificity for a flavivirus RdRp, analysis and mechanism, overview. Viral protein NS5 has the ability to bind RNA with high affinity Dengue virus ?
-
 ?
additional information formation of an RNA-RNA complex between the 5' and 3' terminal nucleotides of the viral genome is necessary for polymerase activity, template specificity for a flavivirus RdRp, analysis and mechanism, overview. Viral protein NS5 has the ability to bind RNA with high affinity Yellow fever virus ?
-
 ?
additional information formation of an RNA-RNA complex between the 5' and 3' terminal nucleotides of the viral genome is necessary for polymerase activity, template specificity for a flavivirus RdRp, analysis and mechanism, overview. Viral protein NS5 has the ability to bind RNA with high affinity Japanese encephalitis virus ?
-
 ?
additional information formation of an RNA-RNA complex between the 5' and 3' terminal nucleotides of the viral genome is necessary for polymerase activity, template specificity for a flavivirus RdRp, analysis and mechanism, overview. Viral protein NS5 has the ability to bind RNA with high affinity Saint Louis encephalitis virus ?
-
 ?
additional information formation of an RNA-RNA complex between the 5' and 3' terminal nucleotides of the viral genome is necessary for polymerase activity, template specificity for a flavivirus RdRp, analysis and mechanism, overview. Viral protein NS5 has the ability to bind RNA with high affinity West Nile virus ?
-
 ?
additional information NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis Japanese encephalitis virus JEV ?
-
 ?
additional information formation of an RNA-RNA complex between the 5' and 3' terminal nucleotides of the viral genome is necessary for polymerase activity, template specificity for a flavivirus RdRp, analysis and mechanism, overview. Viral protein NS5 has the ability to bind RNA with high affinity Japanese encephalitis virus JEV ?
-
 ?
additional information NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis Saint Louis encephalitis virus SLEV ?
-
 ?
additional information formation of an RNA-RNA complex between the 5' and 3' terminal nucleotides of the viral genome is necessary for polymerase activity, template specificity for a flavivirus RdRp, analysis and mechanism, overview. Viral protein NS5 has the ability to bind RNA with high affinity Saint Louis encephalitis virus SLEV ?
-
 ?
additional information NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis Dengue virus DENV ?
-
 ?
additional information formation of an RNA-RNA complex between the 5' and 3' terminal nucleotides of the viral genome is necessary for polymerase activity, template specificity for a flavivirus RdRp, analysis and mechanism, overview. Viral protein NS5 has the ability to bind RNA with high affinity Dengue virus DENV ?
-
 ?
additional information NS5 is the largest and the most conserved of the flavivirus proteins. It contains an N-terminal methyl transferase domain and a C-terminal RdRp domain. The main enzymatic activity observed in extracts of infected cells with endogenous templates is the elongation of already initiated RNA synthesis West Nile virus WNV ?
-
 ?
additional information formation of an RNA-RNA complex between the 5' and 3' terminal nucleotides of the viral genome is necessary for polymerase activity, template specificity for a flavivirus RdRp, analysis and mechanism, overview. Viral protein NS5 has the ability to bind RNA with high affinity West Nile virus WNV ?
-
 ?

Synonyms

Synonyms Comment Organism
NS5
-
 Japanese encephalitis virus
RDRP
-
 Dengue virus
RDRP
-
 Yellow fever virus
RDRP
-
 Japanese encephalitis virus
RDRP
-
 Saint Louis encephalitis virus
RDRP
-
 West Nile virus