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Literature summary for 2.7.7.48 extracted from
- Role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity (2013), J. Mol. Biol., 425, 2279-2287.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the HCV replication reaction in vitro is stimulated by the protein NS5A in a template-specific manner | Hepacivirus C | |
| additional information | the HCV replication reaction in vitro is stimulated by the protein NS5A in a template-specific manner | Infectious bursal disease virus | |
| additional information | the HCV replication reaction in vitro is stimulated by the protein NS5A in a template-specific manner | Enterovirus A71 | |
| additional information | the HCV replication reaction in vitro is stimulated by the protein NS5A in a template-specific manner | infectious pancreatic necrosis virus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nucleoside triphosphate + RNAn | Foot-and-mouth disease virus | - |
diphosphate + RNAn+1 | - |
? |  |
| nucleoside triphosphate + RNAn | Hepacivirus C | - |
diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | Infectious bursal disease virus | - |
diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | Norwalk virus | - |
diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | Enterovirus A71 | - |
diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | infectious pancreatic necrosis virus | - |
diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | Foot-and-mouth disease virus C-S8c1 | - |
diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | Infectious bursal disease virus VP1 | - |
diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | Hepacivirus C NS5B | - |
diphosphate + RNAn+1 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Enterovirus A71 | - |
- |
- |
| Foot-and-mouth disease virus | - |
- |
- |
| Foot-and-mouth disease virus C-S8c1 | - |
- |
- |
| Hepacivirus C | - |
strains jfh1 and j6, genotype 2a HCV | - |
| Hepacivirus C NS5B | - |
strains jfh1 and j6, genotype 2a HCV | - |
| Infectious bursal disease virus | - |
- |
- |
| Infectious bursal disease virus VP1 | - |
- |
- |
| infectious pancreatic necrosis virus | P22173 | a birnavirus | - |
| Norwalk virus | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| nucleoside triphosphate + RNAn | - |
Foot-and-mouth disease virus | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | - |
Hepacivirus C | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | - |
Infectious bursal disease virus | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | - |
Norwalk virus | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | - |
Enterovirus A71 | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | - |
infectious pancreatic necrosis virus | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | rNTP substrate binding structure, multistep model of nucleotide incorporation, overview | Foot-and-mouth disease virus | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | rNTP substrate binding structure, multistep model of nucleotide incorporation, overview | Hepacivirus C | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | rNTP substrate binding structure, multistep model of nucleotide incorporation, overview | Infectious bursal disease virus | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | rNTP substrate binding structure, multistep model of nucleotide incorporation, overview | Norwalk virus | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | rNTP substrate binding structure, multistep model of nucleotide incorporation, overview | Enterovirus A71 | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | rNTP substrate binding structure, multistep model of nucleotide incorporation, overview | infectious pancreatic necrosis virus | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | - |
Foot-and-mouth disease virus C-S8c1 | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | rNTP substrate binding structure, multistep model of nucleotide incorporation, overview | Foot-and-mouth disease virus C-S8c1 | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | - |
Infectious bursal disease virus VP1 | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | rNTP substrate binding structure, multistep model of nucleotide incorporation, overview | Infectious bursal disease virus VP1 | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | - |
Hepacivirus C NS5B | diphosphate + RNAn+1 | - |
? | |
| nucleoside triphosphate + RNAn | rNTP substrate binding structure, multistep model of nucleotide incorporation, overview | Hepacivirus C NS5B | diphosphate + RNAn+1 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | enzyme domain structure, structure-function relationship, overview | Foot-and-mouth disease virus |
| More | enzyme domain structure, structure-function relationship, overview | Norwalk virus |
| More | open and closed enzyme conformation, and enzyme domain structure, structure-function relationship, overview | Hepacivirus C |
| More | open and closed enzyme conformation, and enzyme domain structure, structure-function relationship, overview | Infectious bursal disease virus |
| More | open and closed enzyme conformation, and enzyme domain structure, structure-function relationship, overview | Enterovirus A71 |
| More | open and closed enzyme conformation, and enzyme domain structure, structure-function relationship, overview | infectious pancreatic necrosis virus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| NS5B polymerase | - |
Hepacivirus C |
| RDRP | - |
Foot-and-mouth disease virus |
| RDRP | - |
Hepacivirus C |
| RDRP | - |
Infectious bursal disease virus |
| RDRP | - |
Norwalk virus |
| RDRP | - |
Enterovirus A71 |
| RDRP | - |
infectious pancreatic necrosis virus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | overall enzyme structure analysis from crystal structure, PDB ID 1WNE. Structure solution of RdRP-RNA-rNTP complexes, overview | Foot-and-mouth disease virus |
| additional information | overall enzyme structure analysis from crystal structure, PDB ID 3ZED. Structure solution of RdRP-RNA-rNTP complexes, open and closed conformations of the B-loop in IBDV VP, overview | infectious pancreatic necrosis virus |
| additional information | overall enzyme structure analysis from crystal structure, PDB IDs 2PUS and 2R70. Structure solution of RdRP-RNA-rNTP complexes, conformational changes in the B-loop of RdRP, overview | Infectious bursal disease virus |
| additional information | overall enzyme structure analysis from crystal structure, PDB IDs 2XXD and 4E76. Structure solution of RdRP-RNA-rNTP complexes, overview | Hepacivirus C |
| additional information | overall enzyme structure analysis from crystal structure, PDB IDs 3N6L, 3N6N, and 3N6M, conformational changes in the B-loop of RdRP. Structure solution of RdRP-RNA-rNTP complexes, overview | Enterovirus A71 |
| additional information | overall enzyme structure analysis from crystal structures, PDB IDs 1SH0, 3BSO, and 1SH3. Structure solution of RdRP-RNA-rNTP complexes, conformational changes in the B-loop of RdRP, overview | Norwalk virus |
| physiological function | role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics | Foot-and-mouth disease virus |
| physiological function | role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics | Hepacivirus C |
| physiological function | role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics | Infectious bursal disease virus |
| physiological function | role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics | Norwalk virus |
| physiological function | role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics | Enterovirus A71 |
| physiological function | role of motif B loop in allosteric regulation of RNA-dependent RNA polymerization activity, allosteric factors regulating B-loop dynamics | infectious pancreatic necrosis virus |
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