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Literature summary for 2.7.7.48 extracted from

  • Wang, Y.; Qu, J.; Ji, S.; Wallace, A.J.; Wu, J.; Li, Y.; Gopalan, V.; Ding, B.
    A land plant-specific transcription factor directly enhances transcription of a pathogenic noncoding RNA template by DNA-dependent RNA polymerase II (2016), Plant Cell, 28, 1094-1107.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information The Nicotiana benthamiana canonical 9-zinc finger (ZF) transcription factor IIIA (TFIIIA-9ZF) as well as its variant TFIIIA-7ZF both interact with (+)-PSTVd, but only TFIIIA-7ZF interacts with (-)-PSTVd. TFIIIA-7ZF is found in the nucleoplasm and nucleolus, in contrast to the strictly nucleolar localization of TFIIIA-9ZF. Overexpression of TFIIIA-7ZF enhances PSTVd replication in planta, the land plant-specific transcription factor directly enhances transcription of a pathogenic noncoding RNA template by DNA-dependent RNA polymerase II. TFIIIA-7ZF is a cellular transcription factor that acts in DdRP-catalyzed RNA-templated transcription, highlighting both the extraordinary evolutionary adaptation of viroids and the potential of DdRPs for a broader role in cellular processes. Subcellular localization of TFIIIA-7ZF and TFIIIA-9ZF in Nicotiana benthamiana leaves infected by PSTVd, overview Potato spindle tuber viroid

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Potato spindle tuber viroid Potato spindle tuber viroid replication in the nucleoplasm generates (-)-PSTVd intermediates and (+)-PSTVd copies. The Nicotiana benthamiana canonical 9-zinc finger (ZF) transcription factor IIIA (TFIIIA-9ZF) as well as its variant TFIIIA-7ZF both interact with (+)-PSTVd, but only TFIIIA-7ZF interacts with (-)-PSTVd. TFIIIA-7ZF is found in the nucleoplasm and nucleolus, in contrast to the strictly nucleolar localization of TFIIIA-9ZF. The DNA-dependent RNA polymerase II interacts with the (+)- and (2)-PSTVd RNA in vivo ?
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Organism

Organism UniProt Comment Textmining
Potato spindle tuber viroid
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Potato spindle tuber viroid (PSTVd) RNA genome in Solanum lycopersicum
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Potato spindle tuber viroid replication in the nucleoplasm generates (-)-PSTVd intermediates and (+)-PSTVd copies. The Nicotiana benthamiana canonical 9-zinc finger (ZF) transcription factor IIIA (TFIIIA-9ZF) as well as its variant TFIIIA-7ZF both interact with (+)-PSTVd, but only TFIIIA-7ZF interacts with (-)-PSTVd. TFIIIA-7ZF is found in the nucleoplasm and nucleolus, in contrast to the strictly nucleolar localization of TFIIIA-9ZF. The DNA-dependent RNA polymerase II interacts with the (+)- and (2)-PSTVd RNA in vivo Potato spindle tuber viroid ?
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General Information

General Information Comment Organism
malfunction suppression of Nicotiana benthamiana canonical 9-zinc finger transcription factor TFIIIA-7ZF reduces PSTVd replication, and overexpression of TFIIIA-7ZF enhances PSTVd replication in planta Potato spindle tuber viroid
physiological function the DNA-dependent RNA polymerase (DdRP) from Potato spindle tuber viroid (PSTVd) RNA genome in Solanum lycopersicum possesses RNA-dependent RNA polymerase activity. A land plant-specific transcription factor directly enhances transcription of a pathogenic noncoding RNA template by DNA-dependent RNA polymerase II Potato spindle tuber viroid