Literature summary for 2.7.7.59 extracted from

van Heeswijk, W.C.; Rabenberg, M.; Westerhoff, H.V.; Kahn, D.
The genes of the glutamine synthetase adenylylation cascade are not regulated by nitrogen in Escherichia coli (1993), Mol. Microbiol., 9, 443-457.

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Cloned(Commentary)

Cloned (Comment)	Organism
gene glnD, DNA and amino acid sequence determination and analysis, chromosome mapping, overexpression and functional complementation in Escherichia coli strain DH5	Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
UTP + [protein-PII]	Escherichia coli	the enzyme is constitutively expressed at a low level. The functioning of the glutamine synthetase adenylylation cascade is regulated by modulation of the activities of uridylyltransferase and adenylyltransferase, rather than by changes in the expression of their genes	diphosphate + uridylyl-[protein-PII]	-	?

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P27249	gene glnD	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
UTP + [protein-PII]	-	Escherichia coli	diphosphate + uridylyl-[protein-PII]	-	?
UTP + [protein-PII]	the enzyme is constitutively expressed at a low level. The functioning of the glutamine synthetase adenylylation cascade is regulated by modulation of the activities of uridylyltransferase and adenylyltransferase, rather than by changes in the expression of their genes	Escherichia coli	diphosphate + uridylyl-[protein-PII]	-	?

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Release 2023.1 (January 2023)