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Literature summary for 2.7.7.6 extracted from

  • Brookes, E.; Pombo, A.
    Modifications of RNA polymerase II are pivotal in regulating gene expression states (2009), EMBO Rep., 10, 1213-1219.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information RNA polymerase complex with associated proteins, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
Homo sapiens 5634
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens RNA polymerase II phosphorylation during paused, active and poised transcription cycles with in itiation and elongation stages and at different phosphorylation stages, RNA polymerase II and histone modification profiles across genes in paused, active and poised states, and RNAPII regulation mechanisms at active genes, detailed overview. In embryonic stem cells, silent developmental regulator genes that are repressed by Polycomb are associated with a form of RNAPII that can elongate through coding regions but that lacks the post-translational modifications that are important for cou­pling RNA synthesis to co-transcriptional maturation ?
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?
nucleoside triphosphate + RNAn Homo sapiens RNAPIIis recruited to gene promoters in a hypo-phosphorylated state diphosphate + RNAn+1
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information in embryonic stem cells, silent developmental regulator genes that are repressed by Polycomb are associated with a form of RNAPII that can elongate through coding regions but that lacks the post-translational modifications that are important for cou­pling RNA synthesis to co-transcriptional maturation Homo sapiens
phosphoprotein RNAPIIis recruited to gene promoters in a hypophosphorylated state, but is phosphorylated at Ser5, Ser7, and Ser2. Its escape from the promoter requires TFIIH-mediated phosphorylation of Ser5, the onset of productive elongation requires P-TEFb, which phosphorylates Ser2 residues of the RNAPII C-terminal domain to produce stable elongation com­plexes. Absence of Ser 2Pat poised RNAPIIcomplexes is likely to disrupt co-transcriptional RNAmaturation and histone modification to help maintain the silent state, whereas binding and transcription by RNAPII counteract Polycomb-mediated chromatin conden­sation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
embryonic stem cell in embryonic stem cells, silent developmental regulator genes that are repressed by Polycomb are associated with a form of RNAPII that can elongate through coding regions but that lacks the post-translational modifications that are important for cou­pling RNA synthesis to co-transcriptional maturation Homo sapiens
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additional information RNAPII complexes are also located at silent genes in promoter-proximal paused configurations that provide dynamic transcriptional regulation downstream from ini­tiation Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information RNA polymerase II phosphorylation during paused, active and poised transcription cycles with in itiation and elongation stages and at different phosphorylation stages, RNA polymerase II and histone modification profiles across genes in paused, active and poised states, and RNAPII regulation mechanisms at active genes, detailed overview. In embryonic stem cells, silent developmental regulator genes that are repressed by Polycomb are associated with a form of RNAPII that can elongate through coding regions but that lacks the post-translational modifications that are important for cou­pling RNA synthesis to co-transcriptional maturation Homo sapiens ?
-
?
nucleoside triphosphate + RNAn RNAPIIis recruited to gene promoters in a hypo-phosphorylated state Homo sapiens diphosphate + RNAn+1
-
?

Synonyms

Synonyms Comment Organism
RNA polymerase II
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Homo sapiens
RNAPII
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Homo sapiens