Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | Top1 inhibition favors Pol II escape from a promoter-proximal pausing site of the human HIF-1alpha gene in living cells. Top1 inhibition can trigger a transcriptional stress, involving antisense transcription and increased chromatin accessibility, which is dependent on cdk activity and deregulated Pol II pausing | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
carcinoma cell | - |
Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
HCT-116 cell | - |
Homo sapiens | - |
JURKAT cell | - |
Homo sapiens | - |
MRC-5 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Pol II | - |
Homo sapiens |
RNA polymerase II | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1alpha gene locus | Homo sapiens |