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Literature summary for 2.7.7.6 extracted from

  • Pesavento, C.; Hengge, R.
    The global repressor FliZ antagonizes gene expression by sigmaS-containing RNA polymerase due to overlapping DNA binding specificity (2012), Nucleic Acids Res., 40, 4783-4793.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information RNAP contains the vegetative sigma subunit sigma70 (RpoD) and/or the flagellar sigma factor sigma28 (FliA) Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
additional information FLiZ antagonize sigmaS-dependent gene expression in Escherichia coli. FliZ is an abundant DNA-binding protein and a global regulatory protein under the control of the flagellar master regulator FlhDC. It inhibits gene expression mediated by sigmaS by recognizing operator sequences that resemble the -10 region of sigmaS-dependent promoter. FLiZ plays a pivotal role in the decision between alternative life-styles, i.e. FlhDC-controlled flagellum-based motility or pS-dependent curli fimbriae-mediated adhesion and biofilm formation. FliZ is a global repressor with a DNA sequence specificity overlapping that of sigmaS–containing RNA polymerase, mechanism, overview Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
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Subunits

Subunits Comment Organism
More RNAP contains the vegetative sigma subunit sigma70 (RpoD) and/or the flagellar sigma factor sigma28 (FliA) Escherichia coli

Synonyms

Synonyms Comment Organism
RNAP
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Escherichia coli
sigmaS-containing RNA polymerase
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Escherichia coli

General Information

General Information Comment Organism
physiological function the enzyme activates genes for high affinity nutrient scavenging and motility Escherichia coli