Application | Comment | Organism |
---|---|---|
medicine | the structure of CMS of Mycobacterium tuberculosis could be a starting point for structure-based design of new antituberculosis drugs | Mycobacterium tuberculosis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.043 | - |
2-C-methyl-D-erythritol 4-phosphate | calculated affinity | Mycobacterium tuberculosis | |
0.092 | - |
CTP | calculated affinity | Mycobacterium tuberculosis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Mycobacterium tuberculosis | |
Mn2+ | - |
Mycobacterium tuberculosis | |
Zn2+ | - |
Mycobacterium tuberculosis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + 2-C-methyl-D-erythritol 4-phosphate | Mycobacterium tuberculosis | - |
diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol | - |
? | |
CTP + 2-C-methyl-D-erythritol 4-phosphate | Mycobacterium tuberculosis H37Rv | - |
diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | P9WKG9 | - |
- |
Mycobacterium tuberculosis H37Rv | P9WKG9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CTP + 2-C-methyl-D-erythritol 4-phosphate | - |
Mycobacterium tuberculosis | diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol | - |
? | |
CTP + 2-C-methyl-D-erythritol 4-phosphate | - |
Mycobacterium tuberculosis H37Rv | diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
2C-methyl-D-erythritol-4-phosphate cytidylyltransferase | - |
Mycobacterium tuberculosis |
CMS | - |
Mycobacterium tuberculosis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 9 | - |
Mycobacterium tuberculosis |
General Information | Comment | Organism |
---|---|---|
physiological function | 2C-methyl-D-erythritol-4-phosphate cytidylyltransferase is the third enzyme in the MEP pathway for isoprenoid biosynthesis | Mycobacterium tuberculosis |