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Literature summary for 2.7.7.62 extracted from

  • Thomas, M.G.; Thompson, T.B.; Rayment, I.; Escalante-Semerena, J.C.
    Analysis of the adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase (CobU) enzyme of Salmonella typhimurium LT2. Identification of residue His-46 as the site of guanylylation (2000), J. Biol. Chem., 275, 27576-27586.
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
H45A site-directed mutagenesis Salmonella enterica subsp. enterica serovar Typhimurium
H45A/H46A site-directed mutagenesis Salmonella enterica subsp. enterica serovar Typhimurium
H46A site-directed mutagenesis Salmonella enterica subsp. enterica serovar Typhimurium
H46N site-directed mutagenesis Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + adenosylcobinamide phosphate Salmonella enterica subsp. enterica serovar Typhimurium
-
diphosphate + adenosylcobinamide-GDP late steps of cobalamin biosynthesis, involved in de novo synthesis of vitamin B12, nucleotide loop assembly, required for assimilation of exogenous cobinamide and de novo synthesis of adenosylcobalamin, reaction proceeds via a covalently modified CobU-GMP intermediate ?

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Salmonella enterica subsp. enterica serovar Typhimurium

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00000002
-
GTP:guanylyltransferase specific activity, mutant H46A Salmonella enterica subsp. enterica serovar Typhimurium
0.00000003
-
GTP:guanylyltransferase specific activity, mutant H46N Salmonella enterica subsp. enterica serovar Typhimurium
0.000205
-
GTP:guanylyltransferase specific activity, mutant H45A Salmonella enterica subsp. enterica serovar Typhimurium
0.00067
-
GTP:guanylyltransferase specific activity, wild-type Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + adenosylcobinamide phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + adenosylcobinamide-GDP
-
?
GTP + adenosylcobinamide phosphate
-
Salmonella enterica subsp. enterica serovar Typhimurium diphosphate + adenosylcobinamide-GDP late steps of cobalamin biosynthesis, involved in de novo synthesis of vitamin B12, nucleotide loop assembly, required for assimilation of exogenous cobinamide and de novo synthesis of adenosylcobalamin, reaction proceeds via a covalently modified CobU-GMP intermediate ?
additional information CobU is a bifunctional enzyme that has both kinase EC 27.1.1.156 and guanyltransferase EC 2.7.7.62 activities Salmonella enterica subsp. enterica serovar Typhimurium ?
-
?

Synonyms

Synonyms Comment Organism
adenosylcobinamide phosphate guanylyltransferase
-
Salmonella enterica subsp. enterica serovar Typhimurium
AdoCbi-P guanylyltransferase
-
Salmonella enterica subsp. enterica serovar Typhimurium
CobU
-
Salmonella enterica subsp. enterica serovar Typhimurium