Literature summary for 2.7.7.65 extracted from

Rotcheewaphan, S.; Belisle, J.T.; Webb, K.J.; Kim, H.J.; Spencer, J.S.; Borlee, B.R.
Diguanylate cyclase activity of the Mycobacterium leprae T cell antigen ML1419c (2016), Microbiology, 162, 1651-1661.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Pseudomonas aeruginosa PAO1	Mycobacterium leprae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	protein harbors 10 predicted C-terminal transmembrane domains	Mycobacterium leprae	16020	-

Organism

Organism	UniProt	Comment	Textmining
Mycobacterium leprae	Q7AQ57	-	-
Mycobacterium leprae TN	Q7AQ57	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
DgcA	-	Mycobacterium leprae
ML1419	-	Mycobacterium leprae

General Information

General Information	Comment	Organism
physiological function	ML1419c expression in Pseudomonas aeruginosa alters colony morphology, motility and biofilm formation in a manner consistent with increased cyclic di-GMP production. ML1419c expression increases cyclic di-GMP production in cultures in comparison to the vector control. The observed phenotypes and increased levels of cyclic di-GMP can be abrogated by mutation of the active site in ML1419c	Mycobacterium leprae

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Release 2023.1 (January 2023)