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Literature summary for 2.7.7.7 extracted from

  • Wang, T.S.F.
    Eukaryotic DNA polymerases (1991), Annu. Rev. Biochem., 60, 513-552.
    View publication on PubMed
Search for more literature for 2.7.7.7

Activating Compound

Activating Compound Comment Organism Structure
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Gallus gallus
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Drosophila melanogaster
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Mammalia
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Homo sapiens
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Bos taurus
proliferating cell nuclear antigen PCNA, specific auxiliary factor stimulating DNA polymerase delta Xenopus laevis
Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Gallus gallus
Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Drosophila melanogaster
Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Mammalia
Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Homo sapiens
Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Bos taurus
Replication factor A RF-A, multisubunit single-stranded DNA-binding protein, functions as an auxiliary protein for both polymerases alpha and delta, required for initiation and elongation stages of in vitro SV40 DNA replication Xenopus laevis
Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Gallus gallus
Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Drosophila melanogaster
Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Mammalia
Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Homo sapiens
Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Bos taurus
Replication factor C RF-C, multisubunit protein complex with primer/template binding and DNA-dependent ATPase activity, has a profound effect on leading-strand DNA synthesis Xenopus laevis

Cloned(Commentary)

Cloned (Comment) Organism
overview: genetic structure and predicted functional domains Drosophila melanogaster
overview: genetic structure and predicted functional domains Homo sapiens
overview: genetic structure and predicted functional domains Saccharomyces cerevisiae
overview: genetic structure and predicted functional domains Bos taurus
polymerase beta, overexpressed in Escherichia coli Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Bos taurus
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Drosophila melanogaster
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Gallus gallus
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Homo sapiens
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Mammalia
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate DNA polymerase alpha Xenopus laevis
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Bos taurus
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Drosophila melanogaster
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Gallus gallus
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Homo sapiens
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Mammalia
aphidicolin
-
 Saccharomyces cerevisiae
aphidicolin DNA polymerase alpha; DNA polymerase delta; DNA polymerase epsilon Xenopus laevis
Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Bos taurus
Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Drosophila melanogaster
Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Gallus gallus
Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Homo sapiens
Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Mammalia
Carbonyldiphosphonate DNA polymerase delta; no inhibition of polymerase alpha Xenopus laevis
Dideoxynucleoside 5'-triphosphate DNA polymerase beta Bos taurus
Dideoxynucleoside 5'-triphosphate DNA polymerase beta Drosophila melanogaster
Dideoxynucleoside 5'-triphosphate DNA polymerase beta Gallus gallus
Dideoxynucleoside 5'-triphosphate DNA polymerase beta Homo sapiens
Dideoxynucleoside 5'-triphosphate DNA polymerase beta Mammalia
Dideoxynucleoside 5'-triphosphate DNA polymerase beta Xenopus laevis
additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Bos taurus
additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Drosophila melanogaster
additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Gallus gallus
additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Homo sapiens
additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Mammalia
additional information no inhibition by dideoxynucleoside 5'-triphosphate; no inhibition of DNA polymerase beta and gamma by aphidicolin; no inhibition of DNA polymerase beta by N-ethylmaleimide; no inhibition of DNA polymerase beta, gamma, delta, epsilon by 2-(p-n-butylanilino)-2'-deoxyadenosine 5'-triphosphate; no inhibition of polymerase alpha and delta by dideoxynucleoside 5'-triphosphate Xenopus laevis
N-ethylmaleimide DNA polymerase alpha, gamma, delta Bos taurus
N-ethylmaleimide DNA polymerase alpha, gamma, delta Drosophila melanogaster
N-ethylmaleimide DNA polymerase alpha, gamma, delta Gallus gallus
N-ethylmaleimide DNA polymerase alpha, gamma, delta Homo sapiens
N-ethylmaleimide DNA polymerase alpha, gamma, delta Mammalia
N-ethylmaleimide
-
 Saccharomyces cerevisiae
N-ethylmaleimide DNA polymerase alpha, gamma, delta Xenopus laevis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
 Gallus gallus
Mg2+
-
 Drosophila melanogaster
Mg2+
-
 Mammalia
Mg2+
-
 Homo sapiens
Mg2+
-
 Saccharomyces cerevisiae
Mg2+
-
 Bos taurus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
 x * 35000 + x * 125000, ratio 1:1, DNA polymerase gamma Drosophila melanogaster
40000
-
-
 Rattus norvegicus
40000
-
 vertebrates, DNA polymerase beta Gallus gallus
40000
-
 vertebrates, DNA polymerase beta Drosophila melanogaster
40000
-
 vertebrates, DNA polymerase beta Mammalia
40000
-
 vertebrates, DNA polymerase beta Homo sapiens
40000
-
 vertebrates, DNA polymerase beta Bos taurus
40000
-
 vertebrates, DNA polymerase beta Xenopus laevis
40000
-
 1 * 40000, DNA polymerase beta Saccharomyces cerevisiae
47000
-
 4 * 47000, heterotetramer, DNA polymerase gamma Gallus gallus
48000
-
 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Homo sapiens
48000
-
 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Bos taurus
125000
-
 DNA polymerase delta Bos taurus
125000
-
 x * 35000 + x * 125000, ratio 1:1, DNA polymerase gamma Drosophila melanogaster
125000
-
 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Homo sapiens
132000 200000 DNA polymerase epsilon Saccharomyces cerevisiae
140000
-
 DNA polymerase gamma Xenopus laevis
170000
-
-
 Saccharomyces cerevisiae
170000
-
-
 Bos taurus
170000
-
 polymerase delta Homo sapiens
215000
-
 DNA polymerase epsilon Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Rattus norvegicus
-
 diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Saccharomyces cerevisiae
-
 diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Gallus gallus overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Drosophila melanogaster overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Mammalia overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Homo sapiens overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Bos taurus overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Xenopus laevis overview: physiological roles in replication and in DNA repair synthesis diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Gallus gallus DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Drosophila melanogaster DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Mammalia DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Homo sapiens DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Bos taurus DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn Xenopus laevis DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
Drosophila melanogaster
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
Gallus gallus
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
Homo sapiens
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
Mammalia
-
-
-
Rattus norvegicus
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta. Enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent polymerase, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-
Saccharomyces cerevisiae
-
 pol II
-
Xenopus laevis
-
 5 cellular DNA template-dependent DNA polymerases are encoded by distinct genes: polymerase alpha, i.e. pol I, polymerase beta, only in vertebrates, polymerase gamma, required for mitochondrial DNA replication but encoded in the nucleus, polymerase delta, enzymes in mammalian cell contain tightly associated 3'-5'-exonuclease activities, 2 forms: proliferating cell nuclear antigen-dependent and a proliferating cell nuclear antigen-independent, also called DNA polymerase delta II, now named DNA polymerase epsilon, polymerase epsilon, tightly associated 3'-5'-exonuclease activity, formerly named DNA polymerase delta II
-

Purification (Commentary)

Purification (Comment) Organism
polymerase delta Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Gallus gallus
a
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Drosophila melanogaster
a
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Mammalia
a
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Homo sapiens
a
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Rattus norvegicus
a
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Bos taurus
a
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1 mechanism Xenopus laevis
a

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-
placenta
-
 Homo sapiens
-
thymus
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Rattus norvegicus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn
-
 Saccharomyces cerevisiae diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Gallus gallus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Drosophila melanogaster diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Mammalia diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Homo sapiens diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Bos taurus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA substrate: gapped duplex or single-stranded 5'-ends smaller than 100 nucleotides, pol I, pol II and pol III Xenopus laevis diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Gallus gallus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Drosophila melanogaster diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Mammalia diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Homo sapiens diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Bos taurus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn overview: physiological roles in replication and in DNA repair synthesis Xenopus laevis diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Gallus gallus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Drosophila melanogaster diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Mammalia diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Homo sapiens diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Bos taurus diphosphate + DNAn+1
-
 ?
deoxynucleoside triphosphate + DNAn DNA polymerase gamma: required for mitochondrial DNA replication but encoded in the nucleus Xenopus laevis diphosphate + DNAn+1
-
 ?

Subunits

Subunits Comment Organism
?
-
 Saccharomyces cerevisiae
?
-
 Bos taurus
? x * 35000 + x * 125000, ratio 1:1, DNA polymerase gamma Drosophila melanogaster
? DNA polymerase alpha is composed of: 1. a cluster of related high-molecular-weight polypeptides predominantly of 165000-180000 MW containing the catalytic function, 2. a polypeptide of 70000 MW with unknown catalytic function, 3. two polypeptides of 55000-60000 and 48000-49000 associated with primase activity Mammalia
dimer
-
 Drosophila melanogaster
dimer
-
 Saccharomyces cerevisiae
dimer 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Homo sapiens
dimer 1 * 125000 catalytic subunit + 1 * 48000 subunit of unknown function, DNA polymerase delta Bos taurus
monomer
-
 Gallus gallus
monomer
-
 Rattus norvegicus
monomer
-
 Bos taurus
monomer 1 * 215000, DNA polymerase epsilon Homo sapiens
monomer 1 * 140000, DNA polymerase gamma Xenopus laevis
monomer 1 * 40000, DNA polymerase beta Homo sapiens
monomer 1 * 40000, DNA polymerase beta Saccharomyces cerevisiae
monomer 1 * 40000, DNA polymerase beta Xenopus laevis
tetramer 4 * 47000, heterotetramer, DNA polymerase gamma Gallus gallus