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Literature summary for 2.7.7.7 extracted from

  • Wright, G.E.; Hübscher, U.; Khan, N.N.; Focher, F.; Verri, A.
    Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon (1994), FEBS Lett., 341, 128-130.
    View publication on PubMed
Search for more literature for 2.7.7.7

Inhibitors

Inhibitors Comment Organism Structure
2-(p-n-Butylanilino)-2'-deoxyadenosine 5'-triphosphate polymerase delta and epsilon Bos taurus
aphidicolin DNA polymerase alpha; polymerase alpha, delta and epsilon Bos taurus
Carbonyldiphosphonate polymerase alpha, delta and epsilon Bos taurus
additional information inhibitor analysis of calf thymus DNA polymerase alpha, delta and epsilon Bos taurus
N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-triphosphate 100-fold, polymerase delta and epsilon Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Bos taurus
-
 diphosphate + DNAn+1
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 polymerase delta
-
Bos taurus
-
 polymerase alpha
-
Bos taurus
-
 polymerase epsilon
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
 Bos taurus diphosphate + DNAn+1
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.004
-
 Carbonyldiphosphonate polymerase delta, pH 7.5, 37°C Bos taurus
0.0049
-
 Carbonyldiphosphonate polymerase epsilon, pH 7.5, 37°C Bos taurus