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Literature summary for 2.7.7.7 extracted from

  • Nolan, L.L.; Rivera, J.H.; Khan, N.N.
    Isolation and partial characterization of a high-molecular-weight DNA polymerase from Leishmania mexicana (1992), Biochim. Biophys. Acta, 1120, 322-328.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Carbonyldiphosphonate 50% inhibition at 0.15 mM Leishmania mexicana
additional information no inhibition by 2',3'-dideoxythymidine 5'-triphosphate; no inhibition by aphidicolin; no inhibition by ara-CTP Leishmania mexicana
N-ethylmaleimide 50% inhibition at less than 1 mM Leishmania mexicana
Salt sensitive to high ionic strength Leishmania mexicana

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ optimal concentration: 8 mM Leishmania mexicana
Mn2+ can partially replace Mg2+ in activation Leishmania mexicana

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
145000
-
gel filtration Leishmania mexicana

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Leishmania mexicana
-
diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Leishmania mexicana
-
-
-

Purification (Commentary)

Purification (Comment) Organism
DNA polymerase A Leishmania mexicana

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00019
-
polymerase A Leishmania mexicana

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Leishmania mexicana diphosphate + DNAn+1
-
?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
45
-
30 min, less than 10% of initial activity, at high and low protein concentration Leishmania mexicana

pI Value

Organism Comment pI Value Maximum pI Value
Leishmania mexicana
-
-
7