Protein Variants | Comment | Organism |
---|---|---|
F506G | inactive mutant enzyme | Homo sapiens |
F506R | complete loss of de novo DNA synthesis | Homo sapiens |
Y505A | slightly less active in de novo DNA synthesis when compared with wild-type enzyme | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | DNA polymerase lambda is not able to perform de novo DNA synthesis in the absence of a metal ion activator. Synthesis of de novo DNA is much stronger with Mn2+ than with Mg2+ | Homo sapiens | |
Mn2+ | DNA polymerase lambda is not able to perform de novo DNA synthesis in the absence of a metal ion activator. Synthesis of de novo DNA is much stronger with Mn2+ than with Mg2+ | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
deoxynucleoside triphosphate + DNAn | DNA polymerase lambda possesses the ability to synthesise in vitro short fragments of DNA in the absence of a primer-template or even a primer or a template. Amino acid Phe506 of poly lambda is essential for the de novo synthesis | Homo sapiens | diphosphate + DNAn+1 | - |
? | |
deoxynucleoside triphosphate + DNAn | DNA polymerase mu possesses the ability to synthesize in vitro short fragments of DNA in the absence of a primer-template or even a primer or a template. Amino acid Phe506 of poly lambda is essential for the de novo synthesis | Homo sapiens | diphosphate + DNAn+1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA polymerase lambda | - |
Homo sapiens |
DNA polymerase mu | - |
Homo sapiens |