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Literature summary for 2.7.7.7 extracted from

  • Duym, W.W.; Fiala, K.A.; Bhatt, N.; Suo, Z.
    Kinetic effect of a downstream strand and its 5-terminal moieties on single nucleotide gap-filling synthesis catalyzed by human DNA polymerase lambda (2006), J. Biol. Chem., 281, 35649-35655.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn downstream strand and its 5'-phosphate moiety are critical to the polymerase efficiency of the enzyme. Nucleotide-gapped DNA substrates containing a 1,2-dideoxyribose-5-phosphate moiety (a 2-deoxyribose-5-phosphate mimic) moderately decrease the polymerase efficiency by 3.4fold Homo sapiens diphosphate + DNAn+1
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Synonyms

Synonyms Comment Organism
DNA polymerase lambda
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Homo sapiens