Literature summary for 2.7.7.7 extracted from

Richartz, A.; Hoeltje, M.; Brandt, B.; Schaefer-Korting, M.; Hoeltje, H.D.
Targeting human DNA polymerase alpha for the inhibition of keratinocyte proliferation. Part 1. Homology model, active site architecture and ligand binding (2008), J. Enzyme Inhib. Med. Chem., 23, 94-100.

Search for more literature for 2.7.7.7

Inhibitors

Inhibitors	Comment	Organism	Structure
2',3'-dideoxy-ATP	poor inhibitor	Homo sapiens
2-butylanilino-dATP	potent and highly selective inhibitor	Homo sapiens
adefovir diphosphate	-	Homo sapiens
aphidicolin	-	Homo sapiens
lamivudine triphosphate	-	Homo sapiens
stavudine triphosphate	-	Homo sapiens
tenofovir diphosphate	-	Homo sapiens
zidovudine triphosphate	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Homo sapiens	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase alpha	-	Homo sapiens
pol alpha	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00065	-	aphidicolin	-	Homo sapiens
0.001	-	2-butylanilino-dATP	-	Homo sapiens
0.00271	-	adefovir diphosphate	-	Homo sapiens
0.00618	-	tenofovir diphosphate	-	Homo sapiens
0.0188	-	2',3'-dideoxy-ATP	-	Homo sapiens
0.0506	-	lamivudine triphosphate	-	Homo sapiens
0.0569	-	stavudine triphosphate	-	Homo sapiens

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Release 2023.1 (January 2023)