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Literature summary for 2.7.7.7 extracted from

  • Bailey, C.M.; Kasiviswanathan, R.; Copeland, W.C.; Anderson, K.S.
    R964C mutation of DNA polymerase gamma imparts increased stavudine toxicity by decreasing nucleoside analog discrimination and impairing polymerase activity (2009), Antimicrob. Agents Chemother., 53, 2610-2612.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
R964C the mutation demonstrates a 33% decrease in dTTP incorporation efficiency and a 3fold lower d4TTP discrimination relative to that of the wild type enzyme Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?
dTTP + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase gamma
-
Homo sapiens