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Literature summary for 2.7.7.7 extracted from

  • Donny-Clark, K.; Shapiro, R.; Broyde, S.
    Accommodation of an N-(deoxyguanosin-8-yl)-2-acetylaminofluorene adduct in the active site of human DNA polymerase iota: Hoogsteen or Watson-Crick base pairing? (2009), Biochemistry, 48, 7-18.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ DNA polymerase iota contains two catalytic Mg2+ ions in the active site Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
deoxynucleoside triphosphate + DNAn Homo sapiens
-
diphosphate + DNAn+1
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UNA4
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
deoxynucleoside triphosphate + DNAn
-
Homo sapiens diphosphate + DNAn+1
-
?

Synonyms

Synonyms Comment Organism
DNA polymerase iota
-
Homo sapiens
poliota
-
Homo sapiens

General Information

General Information Comment Organism
physiological function DNA polymerase iota is also capable of error-free nucleotide incorporation opposite the bulky major groove adduct N-(deoxyguanosin-8-yl)-2-acetyl-aminofluorene Homo sapiens