Literature summary for 2.7.7.7 extracted from

Kidane, D.; Jonason, A.S.; Gorton, T.S.; Mihaylov, I.; Pan, J.; Keeney, S.; de Rooij, D.G.; Ashley, T.; Keh, A.; Liu, Y.; Banerjee, U.; Zelterman, D.; Sweasy, J.B.
DNA polymerase beta is critical for mouse meiotic synapsis (2010), EMBO J., 29, 410-423.

Search for more literature for 2.7.7.7

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
additional information	DNA polymerase beta localizes to the synaptonemal complex during prophase I of meiosis, the enzyme localizes to synapsed axes during zygonema and pachynema, and it associates with the ends of bivalents during late pachynema and diplonema	Mus musculus	-	-

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
spermatocyte	-	Mus musculus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	-	Mus musculus	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase beta	-	Mus musculus
pol beta	has both polymerase and deoxyribose phosphate lyase activities	Mus musculus

General Information

General Information	Comment	Organism
malfunction	Pol beta-deficient spermatocytes are defective in meiotic chromosome synapsis and undergo apoptosis during prophase I, Pol beta-deficient seminferous tubules have few germ cells, Pol beta-deficient spermatocytes do not progress through meiosis, Pol beta-deficient mice are fertile	Mus musculus
physiological function	DNA polymerase beta is critical for mouse meiotic synapsis, Pol beta is required at a very early step in the processing of meiotic double-strand breaks, at or before the removal of SPO11 from double-strand break ends and the generation of the 3' single-stranded tails necessary for subsequent strand exchange	Mus musculus

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)