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Literature summary for 2.7.7.7 extracted from

  • Bruhn, D.F.; Sammartino, M.P.; Klingbeil, M.M.
    Three mitochondrial DNA polymerases are essential for kinetoplast DNA replication and survival of bloodstream form Trypanosoma brucei (2011), Eukaryot. Cell, 10, 734-743.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information dyskinetoplastid bloodstream form parasites produced during RNAi are not viable, disruption of network-free minicircle replication precedes parasite death Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
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-
-

Synonyms

Synonyms Comment Organism
kDNA replication protein
-
 Trypanosoma brucei
mitochondrial DNA polymerase
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 Trypanosoma brucei
POLIB
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 Trypanosoma brucei
POLIC
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 Trypanosoma brucei
POLID
-
 Trypanosoma brucei

General Information

General Information Comment Organism
malfunction silencing of each polymerase, of mitochondrial DNA polymerases IB, IC, and ID, is lethal, resulting in kDNA loss, persistence of prereplication DNA monomers, and collapse of the mitochondrial membrane potential. Kinetics of kDNA loss during DNA polymerase silencing, overview Trypanosoma brucei
physiological function the parasite's single mitochondrion contains a unique catenated mitochondrial DNA network called kinetoplast DNA (kDNA) that is composed of minicircles and maxicircles. Three kDNA replication proteins (mitochondrial DNA polymerases IB, IC, and ID) are required for bloodstream form parasite viability Trypanosoma brucei