Literature summary for 2.7.7.7 extracted from

Chinchaladze, D.Z.; Prangishvili, D.A.; Scamrov, A.V.; Beabealashvili, R.S.; Dyatkina, N.B.; Krayevsky, A.A.
Nucleoside 5'-triphosphates modified at sugar residues as substrates for DNA polymerase from the thermoacidophilic archaebacterium Sulfolobus acidocaldarius (1989), Biochim. Biophys. Acta, 1008, 113-115.

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Organism

Organism	UniProt	Comment	Textmining
Sulfolobus acidocaldarius	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
deoxynucleoside triphosphate + DNAn	most of the dNTP analogs with modified sugar moiety tested are shown to be specific terminating substrates for the synthesis irreversibly blocking further elongation of a nascent chain. The most powerful inhibitors are the 3'-amino derivatives of deoxy and arabino nucleoside triphosphates, while specific reverse transcriptase inhibitors, 3'-azido and 3'-methoxy derivatives of dNTP, were found to be inactive	Sulfolobus acidocaldarius	diphosphate + DNAn+1	-	?

Synonyms

Synonyms	Comment	Organism
DNA polymerase A	-	Sulfolobus acidocaldarius

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Release 2023.1 (January 2023)