Inhibitors | Comment | Organism | Structure |
---|---|---|---|
UDP | UGPase activity is not significantly decreases in A-549 cells treated with 0.0001-0.003 mM UDP. Activity is significantly decreased at 0.005 mM and 0.1 mM UDP treatments. The inhibition of UGPase activity in A549 cells is 28fold higher at 0.1 mM UDP treatment in comparison to 0.005 mM treatment | Homo sapiens | |
UDP | significant decrease in UGPase activity is observed at 0.002 mM UDP treatment. At 0.005 mM UDP, threefold inhibition is observed in UGPase activity in comparison to 0.1 mM. Comparative analysis of UDP treatment on blood isolate and reference D39 strain shows that 0.005 mM UDP treatments for 1 hour are effective to reduce the bacterial UGPase activity by half than in its host counterpart. UDP mediates decrease in the virulence of Streptococcus pneumoniae | Streptococcus pneumoniae |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UTP + alpha-D-glucose 1-phosphate | Streptococcus pneumoniae | - |
diphosphate + UDP-glucose | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16851 | - |
- |
Streptococcus pneumoniae | A0A0H2ZMV4 | serotype 2 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
THP-1 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UTP + alpha-D-glucose 1-phosphate | - |
Streptococcus pneumoniae | diphosphate + UDP-glucose | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucose pyrophosphorylase | - |
Homo sapiens |
UDP-glucose pyrophosphorylase | - |
Streptococcus pneumoniae |
UGPase | - |
Homo sapiens |
UGPase | - |
Streptococcus pneumoniae |
General Information | Comment | Organism |
---|---|---|
drug target | UDP-mediated decrease in the virulence of Streptococcus pneumoniae. UDP is an effective inhibitor of pneumococcal UGPase | Streptococcus pneumoniae |