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Literature summary for 2.7.8.13 extracted from

  • Struve, W.G.; Sinha, R.K.; Neuhaus, F.C.
    On the initial stage in peptidoglycan synthesis. Phospho-N-acetylmuramyl-pentapeptide translocase (uridine monophosphate) (1966), Biochemistry, 5, 82-93.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Ristomycin
-
Staphylococcus aureus
Vancomycin
-
Staphylococcus aureus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0018
-
UDP-NAc-muramoyl-pentapeptide pH 7.8, 25°C Staphylococcus aureus
0.027
-
UMP pH 7.8, 25°C Staphylococcus aureus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-NAc-muramoyl-pentapeptide + acceptor Staphylococcus aureus biosynthesis of peptidoglycan, first lipid intermediate UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor Staphylococcus aureus Copenhagen biosynthesis of peptidoglycan, first lipid intermediate UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r

Organism

Organism UniProt Comment Textmining
Staphylococcus aureus
-
Copenhagen
-
Staphylococcus aureus Copenhagen
-
Copenhagen
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-NAc-muramoyl-pentapeptide + acceptor equilibrium constant 0.25 Staphylococcus aureus UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor biosynthesis of peptidoglycan, first lipid intermediate Staphylococcus aureus UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor equilibrium constant 0.25 Staphylococcus aureus Copenhagen UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r
UDP-NAc-muramoyl-pentapeptide + acceptor biosynthesis of peptidoglycan, first lipid intermediate Staphylococcus aureus Copenhagen UMP + acceptor-phospho-NAc-muramoyl-pentapeptide
-
r