Literature summary for 2.8.1.1 extracted from

Ramasamy, S.; Singh, S.; Taniere, P.; Langman, M.J.; Eggo, M.C.
Sulfide-detoxifying enzymes in the human colon are decreased in cancer and upregulated in differentiation (2006), Am. J. Physiol. Gastrointest. Liver Physiol., 291, G288-G296.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Butyrate	significantly increase of enzyme activity and expression in human colon cancer cell line HT-29	Homo sapiens
Sulfide	activating at 0.1 mM, inhibitory above 0.3 mM, in human colon cancer cell line HT-29	Homo sapiens

Application

Application	Comment	Organism
medicine	in advanced colon cancers, expression of both thiosulfate sulfurtransferase and mercaptopyruvate sulfurtransferase is markedly reduced, the disease progression correlating with decrease in expression. In human colon cancer cell line HT-29, enzyme activity and expression are significantly increased by butyrate and by histone deacetylaseinhibition. Use of decrease in enzyme expression as a tumor marker for colorectal cancer	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Sulfide	activating at 0.1 mM, inhibitory above 0.3 mM, in human colon cancer cell line HT-29	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
colon	colocalization with mercaptopyruvate sulfurtransferase in luminal mucosal surface. Both enzymes are expressed by colonocytes, but not in mucin-secrteting goblet cells	Homo sapiens	-
HT-29 cell	-	Homo sapiens	-

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Release 2023.1 (January 2023)