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Literature summary for 2.8.1.7 extracted from

  • Biederbick, A.; Stehling, O.; Roesser, R.; Niggemeyer, B.; Nakai, Y.; Elsaesser, H.P.; Lill, R.
    Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation (2006), Mol. Cell. Biol., 26, 5675-5687.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.8.1.7

Cloned(Commentary)

Cloned (Comment) Organism
expression in HeLa cell Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information depletion of cysteine desulfurase in HeLa cells by small interfering RNA approach results in a drastic growth retardation and striking morphological changes of mitochondria. Activities of both mitochondrial and cytosolic Fe/S proteins are strongly impaired Homo sapiens
additional information expression of cysteine desulfurase in enzyme-depleted heLa cells restores both growth and Fe/S protein activities to wild-type levels. No complementation of growth is observed when the murine enzyme is synthesized without its mitochondrial presequence Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol small amounts of isoform Nfs1 Homo sapiens 5829
-
mitochondrion
-
 Mus musculus 5739
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mitochondrion predominat localization of isoform Nfs1 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-