Any feedback?
Literature summary for 2.8.2.14 extracted from
- Hepatic bile salt sulfotransferases in the rat: sulfation of 3beta-hydroxy-5-cholenoate during development (1991), J. Ped. Gastroent. Nutri., 12, 260-268.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| estrogen | isoenzyme BSS I is stimulated by | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 3-ketolithocholate | isoenzyme BSS I completely inhibited, isoenzyme BSS II only 13% | Rattus norvegicus | |
| Co2+ | isoenzyme BSS II | Rattus norvegicus | |
| Cu2+ | inhibits both isoenzymes, BSS I and BSS II | Rattus norvegicus | |
| Zn2+ | isoenzyme BSS II | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | isoenzyme BSS I activity enhanced, BSS II activity inhibited | Rattus norvegicus | |
| Zn2+ | isoenzyme BSS I activity enhanced, BSS II activity inhibited | Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + taurolithocholate | Rattus norvegicus | alternate pathway of bile acid synthesis | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + taurolithocholate | Rattus norvegicus Sprague-Dawley | alternate pathway of bile acid synthesis | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
rat | - |
| Rattus norvegicus | - |
Sprague-Dawley | - |
| Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially, isoenzyme BSS II | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3'-phosphoadenylyl sulfate + taurolithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + taurolithocholate | alternate pathway of bile acid synthesis | Rattus norvegicus | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + taurolithocholate | - |
Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 3'-phosphoadenylyl sulfate + taurolithocholate | alternate pathway of bile acid synthesis | Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate | isoenzyme BSS I | Rattus norvegicus | adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate | isoenzyme BSS I | Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + chenodeoxycholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + cholic acid | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + cholic acid sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + deoxycholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + deoxycholate 12-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + lithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + lithocholate | - |
Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
| 3'-phosphoadenylyl-sulfate + ursodeoxycholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + ursodeoxycholate sulfate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 3beta-hydroxy-5-cholenoate sulfotransferase | - |
Rattus norvegicus |
| BSS I | predominant isoenzyme | Rattus norvegicus |
| BSS II | - |
Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0033 | - |
3-ketolithocholate | pH 6.5, 37°C | Rattus norvegicus | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
