Activating Compound | Comment | Organism | Structure |
---|---|---|---|
estrogen | isoenzyme BSS I is stimulated by | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-ketolithocholate | isoenzyme BSS I completely inhibited, isoenzyme BSS II only 13% | Rattus norvegicus | |
Co2+ | isoenzyme BSS II | Rattus norvegicus | |
Cu2+ | inhibits both isoenzymes, BSS I and BSS II | Rattus norvegicus | |
Zn2+ | isoenzyme BSS II | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | isoenzyme BSS I activity enhanced, BSS II activity inhibited | Rattus norvegicus | |
Zn2+ | isoenzyme BSS I activity enhanced, BSS II activity inhibited | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + taurolithocholate | Rattus norvegicus | alternate pathway of bile acid synthesis | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
3'-phosphoadenylyl sulfate + taurolithocholate | Rattus norvegicus Sprague-Dawley | alternate pathway of bile acid synthesis | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
rat | - |
Rattus norvegicus | - |
Sprague-Dawley | - |
Rattus norvegicus Sprague-Dawley | - |
Sprague-Dawley | - |
Purification (Comment) | Organism |
---|---|
partially, isoenzyme BSS II | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
3'-phosphoadenylyl sulfate + taurolithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
3'-phosphoadenylyl sulfate + taurolithocholate | alternate pathway of bile acid synthesis | Rattus norvegicus | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
3'-phosphoadenylyl sulfate + taurolithocholate | - |
Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
3'-phosphoadenylyl sulfate + taurolithocholate | alternate pathway of bile acid synthesis | Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + taurolithocholate sulfate | - |
? | |
3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate | isoenzyme BSS I | Rattus norvegicus | adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate | - |
? | |
3'-phosphoadenylyl-sulfate + 3beta-hydroxy 5-cholenoate | isoenzyme BSS I | Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + 3beta-hydroxy 5-cholenoate monosulfate | - |
? | |
3'-phosphoadenylyl-sulfate + chenodeoxycholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + chenodeoxycholate 7-sulfate | - |
? | |
3'-phosphoadenylyl-sulfate + cholic acid | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + cholic acid sulfate | - |
? | |
3'-phosphoadenylyl-sulfate + deoxycholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + deoxycholate 12-sulfate | - |
? | |
3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
3'-phosphoadenylyl-sulfate + glycolithocholate | - |
Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate | - |
? | |
3'-phosphoadenylyl-sulfate + lithocholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
3'-phosphoadenylyl-sulfate + lithocholate | - |
Rattus norvegicus Sprague-Dawley | adenosine 3',5'-bisphosphate + lithocholate 3-sulfate | - |
? | |
3'-phosphoadenylyl-sulfate + ursodeoxycholate | - |
Rattus norvegicus | adenosine 3',5'-bisphosphate + ursodeoxycholate sulfate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
3beta-hydroxy-5-cholenoate sulfotransferase | - |
Rattus norvegicus |
BSS I | predominant isoenzyme | Rattus norvegicus |
BSS II | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0033 | - |
3-ketolithocholate | pH 6.5, 37°C | Rattus norvegicus |