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Literature summary for 2.8.3.18 extracted from
- Acetyl:succinate CoA-transferase in procyclic Trypanosoma brucei. Gene identification and role in carbohydrate metabolism (2004), J. Biol. Chem., 279, 45337-45346.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | the enzyme seems to be a logical target for broad-spectrum anti-parasitic drugs | Trypanosoma brucei |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Trypanosoma brucei | Trypanosoma brucei |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 53000 | - |
SDS-PAGE | Trypanosoma brucei |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + acetyl-CoA | Trypanosoma brucei | acetate producing pathway | acetate + succinyl-CoA | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Trypanosoma brucei | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| procyclic form | procyclic cell | Trypanosoma brucei | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.01 | - |
knock out mutant | Trypanosoma brucei |
| 0.058 | - |
wildtype | Trypanosoma brucei |
| 0.157 | - |
rescued clone, i.e. knock out mutant transfected with the vector pTSArib.ASCT, resulting in overexpression | Trypanosoma brucei |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinate + acetyl-CoA | - |
Trypanosoma brucei | acetate + succinyl-CoA | - |
? | |
| succinate + acetyl-CoA | acetate producing pathway | Trypanosoma brucei | acetate + succinyl-CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| acetyl:succinate CoA-transferase | - |
Trypanosoma brucei |
| ASCT | - |
Trypanosoma brucei |
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Release 2023.1 (January 2023)
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