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Literature summary for 2.8.3.5 extracted from

  • Orii, K.E.; Fukao, T.; Song, X.Q.; Mitchell, G.A.; Kondo, N.
    Liver-specific silencing of the human gene encoding succinyl-CoA: 3-ketoacid CoA transferase (2008), Tohoku J. Exp. Med., 215, 227-236.
    View publication on PubMed
Search for more literature for 2.8.3.5

Application

Application Comment Organism
medicine hereditary SCOT deficiency is one cause of ketoacidosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the DNA region between -2168 and -361 appears to inhibit the SCOT promoter activity in HepG2 cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + a 3-oxo acid Homo sapiens
-
 succinate + a 3-oxoacyl-CoA
-
 ?
succinyl-CoA + acetoacetate Homo sapiens the activation of acetoacetate to acetoacetyl-CoA by SCOT is essential for use of ketone bodies as an energy source succinate + acetoacetyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P55809
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Chang cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-
hepatoma cell line H1e human hepatoma cell line, but no detection in normal hepatocytes, HepG2 hepatoma cells and liver tissues Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + a 3-oxo acid
-
 Homo sapiens succinate + a 3-oxoacyl-CoA
-
 ?
succinyl-CoA + acetoacetate
-
 Homo sapiens succinate + acetoacetyl-CoA
-
 ?
succinyl-CoA + acetoacetate the activation of acetoacetate to acetoacetyl-CoA by SCOT is essential for use of ketone bodies as an energy source Homo sapiens succinate + acetoacetyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
SCOT
-
 Homo sapiens
succinyl-CoA:3-ketoacid CoA transferase
-
 Homo sapiens