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Literature summary for 2.8.3.5 extracted from

  • Skinner, R.; Trujillo, A.; Ma, X.; Beierle, E.
    Ketone bodies inhibit the viability of human neuroblastoma cells (2009), J. Pediatr. Surg., 44, 212-216.
    View publication on PubMed
Search for more literature for 2.8.3.5

Application

Application Comment Organism
medicine dietary manipulation using ketone bodies in accordance with SCOT expression may be a novel therapeutic strategy for neuroblastoma Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
succinyl-CoA + acetoacetate Homo sapiens
-
 succinate + acetoacetyl-CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast from foreskin Homo sapiens
-
HFF-1 cell
-
 Homo sapiens
-
neuroblastoma cell decreased expression of SCOT protein, neuroblastoma cells are unable to use ketone bodies as an energy source Homo sapiens
-
SK-N-AS cell decreased expression of SCOT protein, neuroblastoma cells are unable to use ketone bodies as an energy source Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
succinyl-CoA + acetoacetate
-
 Homo sapiens succinate + acetoacetyl-CoA
-
 ?

Synonyms

Synonyms Comment Organism
SCOT
-
 Homo sapiens
succinyl-coenzyme A:3-oxoacid coenzyme A transferase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
succinyl-CoA
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism SCOT is a key enzyme involved in ketone body metabolism Homo sapiens