Cloned (Comment) | Organism |
---|---|
DNA sequence determination and analysis | Rattus norvegicus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00089 | - |
retinyl palmitate | isozyme ES3, pH 8.0, 37°C | Rattus norvegicus | |
0.0012 | - |
retinyl palmitate | isozyme ES10, pH 8.0, 37°C | Rattus norvegicus | |
0.0014 | - |
retinyl palmitate | isozyme ES4, pH 8.0, 37°C | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Rattus norvegicus | phylogenetic tree for rat liver carboxylesterases | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | O35535 | male Sprague-Dawley rat, isoenzyme termed D50580 or CE21p, belonging to the nonspecific carboxylesterase family | - |
Rattus norvegicus | O70631 | male Sprague-Dawley rat, isoenzyme termed AB010635, belonging to the nonspecific carboxylesterase CES2 family | - |
Rattus norvegicus | P16303 | male Sprague-Dawley rat, isoenzyme ES10, belonging to the nonspecific carboxylesterase family | - |
Rattus norvegicus | Q63108 | male Sprague-Dawley rat, isoenzyme ES3, belonging to the nonspecific carboxylesterase family | - |
Rattus norvegicus | Q64573 | male Sprague-Dawley rat, isoenzyme ES4, belonging to the nonspecific carboxylesterase family | - |
Rattus norvegicus | Q8K3R0 | male Sprague-Dawley rat, isoenzyme termed AY034877, belonging to the nonspecific carboxylesterase CES2 family | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | N-glycosylated residue is Asn275 | Rattus norvegicus |
glycoprotein | N-glycosylated residue is Asn79 | Rattus norvegicus |
glycoprotein | N-glycosylated residues are Asn261, Asn272, and Asn550 | Rattus norvegicus |
glycoprotein | N-glycosylated residues are Asn79 and Asn489 | Rattus norvegicus |
glycoprotein | N-glycosylated residues are Asn79, Asn107, and Asn489 | Rattus norvegicus |
no glycoprotein | - |
Rattus norvegicus |
Purification (Comment) | Organism |
---|---|
isozyme AB010635 from liver microsomes | Rattus norvegicus |
isozyme AY034877 from liver microsomes | Rattus norvegicus |
isozyme D50580 from liver microsomes | Rattus norvegicus |
isozyme ES10 from liver microsomes | Rattus norvegicus |
isozyme ES3 from liver microsomes | Rattus norvegicus |
isozyme ES4 from liver microsomes | Rattus norvegicus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
a carboxylic ester + H2O = an alcohol + a carboxylate | a catalytic triad is formed by residues Ser221, Glu353, and His466 | Rattus norvegicus | |
a carboxylic ester + H2O = an alcohol + a carboxylate | a catalytic triad is formed by residues Ser224, Glu341, and His452 | Rattus norvegicus | |
a carboxylic ester + H2O = an alcohol + a carboxylate | a catalytic triad is formed by residues Ser227, Glu344, and His456 | Rattus norvegicus | |
a carboxylic ester + H2O = an alcohol + a carboxylate | a catalytic triad is formed by residues Ser230, Glu347, and His459 | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
additional information | no isozyme expression in brain, thymus, heart, and spleen | Rattus norvegicus | - |
skin | - |
Rattus norvegicus | - |
small intestine | - |
Rattus norvegicus | - |
stomach | - |
Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
16.7 | - |
purified isozyme ES4, substrate 4-methylumbelliferyl acetate | Rattus norvegicus |
29.7 | - |
purified isozyme D50580, substrate 4-methylumbelliferyl acetate | Rattus norvegicus |
30.1 | - |
purified isozyme ES3, substrate 4-methylumbelliferyl acetate | Rattus norvegicus |
41.9 | - |
purified isozyme ES10, substrate 4-methylumbelliferyl acetate | Rattus norvegicus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl acetate + H2O | - |
Rattus norvegicus | 4-methylumbelliferone + acetate | - |
? | |
additional information | phylogenetic tree for rat liver carboxylesterases | Rattus norvegicus | ? | - |
? | |
retinyl palmitate + H2O | - |
Rattus norvegicus | retinol + palmitate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CE21p | - |
Rattus norvegicus |
CES2 | - |
Rattus norvegicus |
ES10 | - |
Rattus norvegicus |
ES3 | - |
Rattus norvegicus |
ES4 | - |
Rattus norvegicus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00083 | - |
retinyl palmitate | isozyme AB010635, pH 8.0, 37°C | Rattus norvegicus | |
0.0028 | 0.0045 | retinyl palmitate | isozyme D50580, pH 8.0, 37°C | Rattus norvegicus | |
0.0032 | - |
retinyl palmitate | isozyme ES3, pH 8.0, 37°C | Rattus norvegicus | |
0.004 | - |
retinyl palmitate | isozyme ES10, pH 8.0, 37°C | Rattus norvegicus | |
0.0075 | - |
retinyl palmitate | isozyme ES4, pH 8.0, 37°C | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.3 | - |
assay at, substrate 4-methylumbelliferyl acetate | Rattus norvegicus |
8 | - |
assay at, substrate retinyl palmitate | Rattus norvegicus |
Organism | Comment | pI Value Maximum | pI Value |
---|---|---|---|
Rattus norvegicus | isozyme AB010635, isoelectric focusing | - |
4.8 |
Rattus norvegicus | isozyme D50580, isoelectric focusing | - |
5.3 |
Rattus norvegicus | isozyme ES3, isoelectric focusing | - |
5.7 |
Rattus norvegicus | isozyme AY034877, isoelectric focusing | - |
6 |
Rattus norvegicus | isozyme ES10, isoelectric focusing | - |
6.1 |
Rattus norvegicus | isozyme ES4, isoelectric focusing | - |
6.7 |