Inhibitors | Comment | Organism | Structure |
---|---|---|---|
benzil | specific CES inhibitor | Homo sapiens | |
chlorpyrifos | - |
Homo sapiens | |
methyl paraoxon | - |
Homo sapiens | |
paraoxon | non-specific CES inhibitor, CES1 protein expression in cells is unaffected by a 24 h paraoxon treatment, suggesting that the reduced hydrolytic activity is due to covalent inhibition of CES1 by oxons and not down-regulation of expression | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | - |
Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
THP-1 cell | isozyme CES1 but not CES2 is expressed in THP-1 cells | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-methylumbelliferyl oleate + H2O | - |
Homo sapiens | 4-methylumbelliferol + oleate | - |
? | |
4-nitrophenyl valerate + H2O | - |
Homo sapiens | 4-nitrophenol + valerate | - |
? | |
cholesteryl oleate + H2O | - |
Homo sapiens | cholesterol + oleate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxylesterase 1 | - |
Homo sapiens |
CEH | - |
Homo sapiens |
CES1 | isozyme | Homo sapiens |
cholesteryl ester hydrolase | - |
Homo sapiens |
HCE1 | - |
Homo sapiens |
TGH | - |
Homo sapiens |
triacylglycerol hydrolase | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00000021 | - |
- |
Homo sapiens | chlorpyrifos | |
0.00000029 | - |
- |
Homo sapiens | paraoxon | |
0.000049 | - |
- |
Homo sapiens | methyl paraoxon | |
0.00016 | - |
- |
Homo sapiens | benzil |