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Literature summary for 3.1.1.1 extracted from
- Detection and quantification of carboxylesterase 2 activity by capillary electrophoresis (2011), Anal. Chem., 83, 881-887.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| bis-4-nitrophenyl phosphate | irreversible carboxylesterase inhibitor | Bos taurus |  |
| bis-4-nitrophenyl phosphate | irreversible carboxylesterase inhibitor | Canis lupus familiaris | |
| bis-4-nitrophenyl phosphate | irreversible carboxylesterase inhibitor | Equus caballus | |
| bis-4-nitrophenyl phosphate | irreversible carboxylesterase inhibitor | Felis catus | |
| bis-4-nitrophenyl phosphate | irreversible carboxylesterase inhibitor | Homo sapiens | |
| bis-4-nitrophenyl phosphate | irreversible carboxylesterase inhibitor | Rattus norvegicus | |
| loperamide | specific carboxylesterase 2 inhibitor | Bos taurus | |
| loperamide | specific carboxylesterase 2 inhibitor | Canis lupus familiaris | |
| loperamide | specific carboxylesterase 2 inhibitor | Equus caballus | |
| loperamide | specific carboxylesterase 2 inhibitor | Felis catus | |
| loperamide | specific carboxylesterase 2 inhibitor, does not inhibit isoform CES1 | Homo sapiens | |
| loperamide | specific carboxylesterase 2 inhibitor | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Canis lupus familiaris | - |
- |
- |
| Equus caballus | - |
- |
- |
| Felis catus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
| serum | - |
Homo sapiens | - |
| serum | - |
Rattus norvegicus | - |
| serum | - |
Bos taurus | - |
| serum | - |
Canis lupus familiaris | - |
| serum | - |
Felis catus | - |
| serum | - |
Equus caballus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methylumbelliferyl acetate + H2O | - |
Homo sapiens | 4-methylumbelliferone + acetate | - |
? | |
| 4-methylumbelliferyl acetate + H2O | - |
Rattus norvegicus | 4-methylumbelliferone + acetate | - |
? | |
| 4-methylumbelliferyl acetate + H2O | - |
Bos taurus | 4-methylumbelliferone + acetate | - |
? | |
| 4-methylumbelliferyl acetate + H2O | - |
Canis lupus familiaris | 4-methylumbelliferone + acetate | - |
? | |
| 4-methylumbelliferyl acetate + H2O | - |
Felis catus | 4-methylumbelliferone + acetate | - |
? | |
| 4-methylumbelliferyl acetate + H2O | - |
Equus caballus | 4-methylumbelliferone + acetate | - |
? | |
| CPT-11 + H2O | other name irinotecan | Homo sapiens | SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2 | - |
? | |
| CPT-11 + H2O | other name irinotecan | Canis lupus familiaris | SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2 | - |
? | |
| CPT-11 + H2O | other name irinotecan | Felis catus | SN-38 + 1,4'-bipiperidine-1'-carboxylic acid + CO2 | - |
? | |
| irinotecan + H2O | other name CPT-11 | Rattus norvegicus | ? | - |
? | |
| irinotecan + H2O | other name CPT-11 | Bos taurus | ? | - |
? | |
| irinotecan + H2O | other name CPT-11 | Equus caballus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carboxylesterase 2 | - |
Homo sapiens |
| carboxylesterase 2 | - |
Rattus norvegicus |
| carboxylesterase 2 | - |
Bos taurus |
| carboxylesterase 2 | - |
Canis lupus familiaris |
| carboxylesterase 2 | - |
Felis catus |
| carboxylesterase 2 | - |
Equus caballus |
| CE-2 | - |
Homo sapiens |
| CES1 | isoform | Homo sapiens |
| CES2 | - |
Rattus norvegicus |
| CES2 | - |
Bos taurus |
| CES2 | - |
Canis lupus familiaris |
| CES2 | - |
Felis catus |
| CES2 | - |
Equus caballus |
| CES2 | isoform | Homo sapiens |
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