Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(2R)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile | about 30% residual activity at 0.1 mM | Homo sapiens | |
amlodipine | about 40% residual activity at 0.1 mM | Homo sapiens | |
atorvastatin | about 45% residual activity at 0.1 mM | Homo sapiens | |
bendroflumethiazide | about 70% residual activity at 0.1 mM | Homo sapiens | |
bisoprolol | about 90% residual activity at 0.1 mM | Homo sapiens | |
carvedilol | about 17% residual activity at 0.1 mM | Homo sapiens | |
clopidogrel | about 15% residual activity at 0.1 mM | Homo sapiens | |
diltiazem | about 23% residual activity at 0.1 mM | Homo sapiens | |
eplerenone | about 80% residual activity at 0.1 mM | Homo sapiens | |
Furosemide | about 78% residual activity at 0.1 mM | Homo sapiens | |
irbesartan | about 75% residual activity at 0.1 mM | Homo sapiens | |
isradipine | about 18% residual activity at 0.1 mM | Homo sapiens | |
lercanidipine | about 78% residual activity at 0.1 mM | Homo sapiens | |
additional information | not inhibited by 0.1 mM dabigatran exilate, dabigatran, pindolol, labetalol, propranolol, metoprolol, sotalol, and azathioprine | Homo sapiens | |
nimodipine | about 70% residual activity at 0.1 mM | Homo sapiens | |
simvastatin | complete inhibition at 0.1 mM | Homo sapiens | |
sirolimus | about 90% residual activity at 0.1 mM | Homo sapiens | |
spironolactone | about 70% residual activity at 0.1 mM | Homo sapiens | |
tacrolimus | about 28% residual activity at 0.1 mM | Homo sapiens | |
valsartan | about 90% residual activity at 0.1 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.901 | - |
ramipril | in 100 mM phosphate buffer at 37°C, pH not specified in the publication | Homo sapiens | |
1.721 | - |
trandolapril | in 100 mM phosphate buffer at 37°C, pH not specified in the publication | Homo sapiens | |
1.734 | - |
enalapril | in 100 mM phosphate buffer at 37°C, pH not specified in the publication | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
? | |
enalapril + H2O | - |
Homo sapiens | ? | - |
? | |
ramipril + H2O | - |
Homo sapiens | ? | - |
? | |
trandolapril + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carboxylesterase 1 | - |
Homo sapiens |
CES1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | carboxylesterase 1 plays a role in the metabolism of several drugs used in the treatment of common conditions, including hypertension, congestive heart failure, and diabetes mellitus | Homo sapiens |