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Literature summary for 3.1.1.1 extracted from

  • Yoshida, T.; Fukami, T.; Kurokawa, T.; Gotoh, S.; Oda, A.; Nakajima, M.
    Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans (2018), Eur. J. Pharm. Sci., 111, 167-176 .
    View publication on PubMed
Search for more literature for 3.1.1.1

Cloned(Commentary)

Cloned (Comment) Organism
recombinant expression of enzyme CES1 in Spodoptera frugiperda Sf21 cells Canis lupus familiaris
recombinant expression of enzyme CES2 in Spodoptera frugiperda Sf21 cells Canis lupus familiaris

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris F1P6W8
-
-
Canis lupus familiaris Q95N05
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenylacetate + H2O
-
 Canis lupus familiaris 4-nitrophenol + acetate
-
 ?
clofibrate + H2O
-
 Canis lupus familiaris clofibric acid + ethanol
-
 ?
clopidogrel + H2O
-
 Canis lupus familiaris clopidogrel carboxylic acid + methanol
-
 ?
fenofibrate + H2O
-
 Canis lupus familiaris fenofibric acid + propan-2-ol
-
 ?
fluorescein diacetate + H2O
-
 Canis lupus familiaris fluorescein + acetate
-
 ?
imidapril + H2O
-
 Canis lupus familiaris imidaprilat + ethanol
-
 ?
irinotecan + H2O
-
 Canis lupus familiaris SN-38 + 1,4'-bipiperidine-1'-carboxylic acid
-
 ?
lidocaine + H2O
-
 Canis lupus familiaris 2,6-xylidine + N,N-diethylglycine
-
 ?
additional information substrate specificity, overview Canis lupus familiaris ?
-
 ?
mycophenolate + H2O
-
 Canis lupus familiaris mycophenolic acid + 2-(morpholin-4-yl)ethanol
-
 ?
N-acetyldapsone + H2O
-
 Canis lupus familiaris dapsone + acetate
-
 ?
oseltamivir + H2O
-
 Canis lupus familiaris oseltamivir carboxylate + ethanol
-
 ?
oxybutynin + H2O
-
 Canis lupus familiaris 2-cyclohexyl-2-phenylglycolic acid + 4-(diethylamino)but-2-yn-1-ol
-
 ?
prilocaine + H2O
-
 Canis lupus familiaris o-toluidine + N-propylalanine
-
 ?
procaine + H2O
-
 Canis lupus familiaris 4-aminobenzoic acid + 2-(diethylamino)ethanol
-
 ?
propanil + H2O
-
 Canis lupus familiaris 3,4-dichloroaniline + propanoate
-
 ?
temocapril + H2O
-
 Canis lupus familiaris temocaprilat + ethanol
-
 ?

Synonyms

Synonyms Comment Organism
carboxylic ester hydrolase
-
 Canis lupus familiaris
CES1
-
 Canis lupus familiaris
CES2
-
 Canis lupus familiaris

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Canis lupus familiaris

General Information

General Information Comment Organism
additional information molecular dynamics simulations, structure comparisons to human CES2 Canis lupus familiaris