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Literature summary for 3.1.1.1 extracted from

  • Imai, T.; Ariyoshi, S.; Ohura, K.; Sawada, T.; Nakada, Y.
    Expression of carboxylesterase isozymes and their role in the behavior of a fexofenadine prodrug in rat skin (2016), J. Pharm. Sci., 105, 714-721 .
    View publication on PubMed
Search for more literature for 3.1.1.1

Inhibitors

Inhibitors Comment Organism Structure
bis-4-nitrophenyl phosphate BNPP, a specific inhibitor of CES, inhibits the hydrolysis of ethyl-FXD in rat skin S9 fraction in a dose-dependent manner, 99% inhibition at 1 mM BNPP Rattus norvegicus
bis-p-nitrophenyl phosphate BNPP, a specific inhibitor of CES, inhibits the hydrolysis of ethyl-FXD in rat skin S9 fraction in a dose-dependent manner, 99% inhibition at 1 mM BNPP Rattus norvegicus
additional information ethopropazine, a specific inhibitor of butyrylcholinesterase (EC 3.1.1.8), shows no inhibitory effect; ethopropazine, a specific inhibitor of butyrylcholinesterase (EC 3.1.1.8), shows no inhibitory effect Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus O35535
-
-
Rattus norvegicus O70177
-
-
Rattus norvegicus Wistar O35535
-
-
Rattus norvegicus Wistar O70177
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skin of 8-week-old rats Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ethyl fexofenadine + H2O
-
 Rattus norvegicus fexofenadine + ethanol
-
 ?
ethyl fexofenadine + H2O
-
 Rattus norvegicus Wistar fexofenadine + ethanol
-
 ?

Synonyms

Synonyms Comment Organism
CES
-
 Rattus norvegicus
CES1
-
 Rattus norvegicus
CES2
-
 Rattus norvegicus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus